Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients

Bernardo Rocco; Maria Chiara Sighinolfi; Marco Sandri; Ahmed Eissa; Ahmed Elsherbiny; Ahmed Zoeir; Harvey Tadzia; Hariharan Palayapalayam; Darian Kameh; Rafael Coelho; Stefano Puliatti; Paola Zuccolotto; Rodolfo Montironi; Peter Wiklund; Salvatore Micali; Giampaolo Bianchi; Vipul Patel

doi:10.1016/j.urology.2019.03.019

Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients

Bernardo Rocco, Maria Chiara Sighinolfi, Marco Sandri, Ahmed Eissa, Ahmed Elsherbiny, Ahmed Zoeir, Harvey Tadzia, Hariharan Palayapalayam, Darian Kameh, Rafael Coelho, Stefano Puliatti, Paola Zuccolotto, Rodolfo Montironi, Peter Wiklund, Salvatore Micali, Giampaolo Bianchi, Vipul Patel

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Our aim was to review and externally validate all the available predictive tools (PTs) predicting extraprostatic extension (EPE) using the area under the curve, calibration plots, and scaled Brier score. A literature search was performed showing 19 models predicting EPE. External validation was carried out on 6360 prostate cancer patients submitted to RP. Most of the PTs showed poor discrimination and unsatisfactory calibration. The majority of the available PTs are not reliable for the prediction of EPE in populations other than the development one; thus, they may not be completely appropriate for patients’ counselling or for surgical strategy preplanning.

Original language	English
Pages (from-to)	8-20
Number of pages	13
Journal	Urology
Volume	129
DOIs	https://doi.org/10.1016/j.urology.2019.03.019
State	Published - Jul 2019
Externally published	Yes

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Rocco, B., Sighinolfi, M. C., Sandri, M., Eissa, A., Elsherbiny, A., Zoeir, A., Tadzia, H., Palayapalayam, H., Kameh, D., Coelho, R., Puliatti, S., Zuccolotto, P., Montironi, R., Wiklund, P., Micali, S., Bianchi, G., & Patel, V. (2019). Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients. Urology, 129, 8-20. https://doi.org/10.1016/j.urology.2019.03.019

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title = "Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients",

abstract = "Our aim was to review and externally validate all the available predictive tools (PTs) predicting extraprostatic extension (EPE) using the area under the curve, calibration plots, and scaled Brier score. A literature search was performed showing 19 models predicting EPE. External validation was carried out on 6360 prostate cancer patients submitted to RP. Most of the PTs showed poor discrimination and unsatisfactory calibration. The majority of the available PTs are not reliable for the prediction of EPE in populations other than the development one; thus, they may not be completely appropriate for patients{\textquoteright} counselling or for surgical strategy preplanning.",

author = "Bernardo Rocco and Sighinolfi, {Maria Chiara} and Marco Sandri and Ahmed Eissa and Ahmed Elsherbiny and Ahmed Zoeir and Harvey Tadzia and Hariharan Palayapalayam and Darian Kameh and Rafael Coelho and Stefano Puliatti and Paola Zuccolotto and Rodolfo Montironi and Peter Wiklund and Salvatore Micali and Giampaolo Bianchi and Vipul Patel",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.urology.2019.03.019",

language = "English",

volume = "129",

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Rocco, B, Sighinolfi, MC, Sandri, M, Eissa, A, Elsherbiny, A, Zoeir, A, Tadzia, H, Palayapalayam, H, Kameh, D, Coelho, R, Puliatti, S, Zuccolotto, P, Montironi, R, Wiklund, P, Micali, S, Bianchi, G & Patel, V 2019, 'Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients', Urology, vol. 129, pp. 8-20. https://doi.org/10.1016/j.urology.2019.03.019

TY - JOUR

T1 - Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients

AU - Rocco, Bernardo

AU - Sighinolfi, Maria Chiara

AU - Sandri, Marco

AU - Eissa, Ahmed

AU - Elsherbiny, Ahmed

AU - Zoeir, Ahmed

AU - Tadzia, Harvey

AU - Palayapalayam, Hariharan

AU - Kameh, Darian

AU - Coelho, Rafael

AU - Puliatti, Stefano

AU - Zuccolotto, Paola

AU - Montironi, Rodolfo

AU - Wiklund, Peter

AU - Micali, Salvatore

AU - Bianchi, Giampaolo

AU - Patel, Vipul

PY - 2019/7

Y1 - 2019/7

N2 - Our aim was to review and externally validate all the available predictive tools (PTs) predicting extraprostatic extension (EPE) using the area under the curve, calibration plots, and scaled Brier score. A literature search was performed showing 19 models predicting EPE. External validation was carried out on 6360 prostate cancer patients submitted to RP. Most of the PTs showed poor discrimination and unsatisfactory calibration. The majority of the available PTs are not reliable for the prediction of EPE in populations other than the development one; thus, they may not be completely appropriate for patients’ counselling or for surgical strategy preplanning.

AB - Our aim was to review and externally validate all the available predictive tools (PTs) predicting extraprostatic extension (EPE) using the area under the curve, calibration plots, and scaled Brier score. A literature search was performed showing 19 models predicting EPE. External validation was carried out on 6360 prostate cancer patients submitted to RP. Most of the PTs showed poor discrimination and unsatisfactory calibration. The majority of the available PTs are not reliable for the prediction of EPE in populations other than the development one; thus, they may not be completely appropriate for patients’ counselling or for surgical strategy preplanning.

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U2 - 10.1016/j.urology.2019.03.019

DO - 10.1016/j.urology.2019.03.019

M3 - Review article

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AN - SCOPUS:85064929913

SN - 0090-4295

VL - 129

SP - 8

EP - 20

JO - Urology

JF - Urology

ER -

Is Extraprostatic Extension of Cancer Predictable? A Review of Predictive Tools and an External Validation Based on a Large and a Single Center Cohort of Prostate Cancer Patients

Abstract

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