Is breast cancer a result of epigenetic responses to traffic-related air pollution? A review of the latest evidence

Debashish Sahay, Mary B. Terry, Rachel Miller

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Environmental toxicants can exert adverse health effects via epigenetic regulation. We conducted a review of studies assessing traffic-related air pollution (TRAP) exposure and breast cancer (BC) risk, and the evidence for epigenetic mediation. 14 epidemiological studies demonstrated associations between TRAP exposure and BC risk, in which a total of 26 comparisons were assessed. 11 of these comparisons reported a positive association; whereas 15 comparisons were negative. Five publications linked TRAP exposure to epigenetic alterations in genes that may be related to BC risk. One animal study provided evidence of TRAP-treatment inducing breast tumorigenesis. Associations between TRAP components polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) and BC risk were more consistent. While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1). Future epigenomic studies with environmental measures are needed to interrogate the relationship between TRAP and BC risk.

Original languageEnglish
Pages (from-to)701-714
Number of pages14
JournalEpigenomics
Volume11
Issue number6
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • DNA methylation
  • breast cancer risk
  • epigenetic regulation
  • traffic-related air pollution
  • windows of susceptibility

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