TY - JOUR
T1 - Irritable bowel syndrome in female patients is associated with alterations in structural brain networks
AU - Labus, Jennifer S.
AU - Dinov, Ivo D.
AU - Jiang, Zhiguo
AU - Ashe-Mcnalley, Cody
AU - Zamanyan, Alen
AU - Shi, Yonggang
AU - Hong, Jui Yang
AU - Gupta, Arpana
AU - Tillisch, Kirsten
AU - Ebrat, Bahar
AU - Hobel, Sam
AU - Gutman, Boris A.
AU - Joshi, Shantanu
AU - Thompson, Paul M.
AU - Toga, Arthur W.
AU - Mayer, Emeran A.
N1 - Funding Information:
This work was funded in part by the National Institutes of Health through Center for Neurobiology (CNS) Grants K08 DK071626, R03 DK084169 (JSL), K23DK073451, R01 AT007137(KT), P50 DK064539 (EAM), R01 DK048351 (EAM), and LONI Grants: P41-EB015922, U24-RR025736, U24-RR026057, R01MH094343, and U01 MH093765. We are also indebted to Cathy Liu for database management and graphic support (P30 DK041301) and the members of the Laboratory of Neuro Imaging (LONI) for support, module definitions and workflow protocol designs.
PY - 2014/1
Y1 - 2014/1
N2 - Alterations in gray matter (GM) density/volume and cortical thickness (CT) have been demonstrated in small and heterogeneous samples of subjects with differing chronic pain syndromes, including irritable bowel syndrome (IBS). Aggregating across 7 structural neuroimaging studies conducted at University of California, Los Angeles, Los Angeles, CA, USA, between August 2006 and April 2011, we examined group differences in regional GM volume in 201 predominantly premenopausal female subjects (82 IBS, mean age: 32 ± 10 SD, 119 healthy controls [HCs], 30 ± 10 SD). Applying graph theoretical methods and controlling for total brain volume, global and regional properties of large-scale structural brain networks were compared between the group with IBS and the HC group. Relative to HCs, the IBS group had lower volumes in the bilateral superior frontal gyrus, bilateral insula, bilateral amygdala, bilateral hippocampus, bilateral middle orbital frontal gyrus, left cingulate, left gyrus rectus, brainstem, and left putamen. Higher volume was found in the left postcentral gyrus. Group differences were no longer significant for most regions when controlling for the Early Trauma Inventory global score, with the exception of the right amygdala and the left postcentral gyrus. No group differences were found for measures of global and local network organization. Compared to HCs, in patients with IBS, the right cingulate gyrus and right thalamus were identified as being significantly more critical for information flow. Regions involved in endogenous pain modulation and central sensory amplification were identified as network hubs in IBS. Overall, evidence for central alterations in patients with IBS was found in the form of regional GM volume differences and altered global and regional properties of brain volumetric networks.
AB - Alterations in gray matter (GM) density/volume and cortical thickness (CT) have been demonstrated in small and heterogeneous samples of subjects with differing chronic pain syndromes, including irritable bowel syndrome (IBS). Aggregating across 7 structural neuroimaging studies conducted at University of California, Los Angeles, Los Angeles, CA, USA, between August 2006 and April 2011, we examined group differences in regional GM volume in 201 predominantly premenopausal female subjects (82 IBS, mean age: 32 ± 10 SD, 119 healthy controls [HCs], 30 ± 10 SD). Applying graph theoretical methods and controlling for total brain volume, global and regional properties of large-scale structural brain networks were compared between the group with IBS and the HC group. Relative to HCs, the IBS group had lower volumes in the bilateral superior frontal gyrus, bilateral insula, bilateral amygdala, bilateral hippocampus, bilateral middle orbital frontal gyrus, left cingulate, left gyrus rectus, brainstem, and left putamen. Higher volume was found in the left postcentral gyrus. Group differences were no longer significant for most regions when controlling for the Early Trauma Inventory global score, with the exception of the right amygdala and the left postcentral gyrus. No group differences were found for measures of global and local network organization. Compared to HCs, in patients with IBS, the right cingulate gyrus and right thalamus were identified as being significantly more critical for information flow. Regions involved in endogenous pain modulation and central sensory amplification were identified as network hubs in IBS. Overall, evidence for central alterations in patients with IBS was found in the form of regional GM volume differences and altered global and regional properties of brain volumetric networks.
KW - Brain network analysis
KW - Chronic pain
KW - Graph theory
KW - Gray matter volume
KW - Irritable bowel syndrome
UR - http://www.scopus.com/inward/record.url?scp=84891826270&partnerID=8YFLogxK
U2 - 10.1016/j.pain.2013.09.020
DO - 10.1016/j.pain.2013.09.020
M3 - Article
C2 - 24076048
AN - SCOPUS:84891826270
SN - 0304-3959
VL - 155
SP - 137
EP - 149
JO - Pain
JF - Pain
IS - 1
ER -