TY - JOUR
T1 - Ironing Out the Details
T2 - How Iron Orchestrates Macrophage Polarization
AU - Xia, Yaoyao
AU - Li, Yikun
AU - Wu, Xiaoyan
AU - Zhang, Qingzhuo
AU - Chen, Siyuan
AU - Ma, Xianyong
AU - Yu, Miao
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (31902200), Special fund for scientific innovation strategy-construction of high level Academy of Agriculture Science (R2017PY-JG001, R2020YJ-YB2002), and Agricultural competitive industry discipline team building project of Guangdong Academy of Agricultural Sciences (202118TD).
Publisher Copyright:
© Copyright © 2021 Xia, Li, Wu, Zhang, Chen, Ma and Yu.
PY - 2021/5/12
Y1 - 2021/5/12
N2 - Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization. Mechanistically, iron orchestrates macrophage polarization through several aspects, including cellular signaling, cellular metabolism, and epigenetic regulation. Therefore, iron modulates the development and progression of multiple macrophage-associated diseases, such as cancer, atherosclerosis, and liver diseases. Collectively, this review highlights the crucial role of iron for macrophage polarization, and indicates the potential application of iron supplementation as an adjuvant therapy in different inflammatory disorders relative to the balance of macrophage polarization.
AB - Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization. Mechanistically, iron orchestrates macrophage polarization through several aspects, including cellular signaling, cellular metabolism, and epigenetic regulation. Therefore, iron modulates the development and progression of multiple macrophage-associated diseases, such as cancer, atherosclerosis, and liver diseases. Collectively, this review highlights the crucial role of iron for macrophage polarization, and indicates the potential application of iron supplementation as an adjuvant therapy in different inflammatory disorders relative to the balance of macrophage polarization.
KW - epigenetics
KW - inflammation
KW - iron
KW - macrophage
KW - metabolism
UR - http://www.scopus.com/inward/record.url?scp=85107074484&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.669566
DO - 10.3389/fimmu.2021.669566
M3 - Review article
C2 - 34054839
AN - SCOPUS:85107074484
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 669566
ER -