Iron(III) salicylates of dipicolylamine bases showing photo-induced anticancer activity and cytosolic localization

Aditya Garai, Ila Pant, Paturu Kondaiah, Akhil R. Chakravarty

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

An iron(III) salicylate having a dipicolylamine base (andpa) with a photoactive anthracenyl moiety is prepared, characterized, and studied for its photo-induced anticancer activity and cellular localization in HeLa and MCF-7 cells. Its phenyl analogue is structurally characterized by X-ray crystallography. The complex has a ternary structure in which the dipicolylamine ligand and salicylic acid in dianionic form (sal) display respective tridentate and bidentate mode of coordination in [Fe(sal)(phdpa)Cl] (1). Complex [Fe(sal)(andpa)Cl] (2) having a pendant anthracenyl moiety shows significant photocytotoxicity in visible light (400-700 nm) giving IC50 values of 8.6 ± 0.7 and 3.4 ± 0.9 μM in HeLa and MCF-7 cells, while being essentially nontoxic in the dark (IC50 > 100 μM). The complex shows cytosolic localization in the cancer cells. Formation of hydroxyl radicals (OH) as the reactive oxygen species is evidenced from the pUC19 DNA photocleavage studies.

Original languageEnglish
Pages (from-to)668-676
Number of pages9
JournalPolyhedron
Volume102
DOIs
StatePublished - 14 Dec 2015
Externally publishedYes

Keywords

  • Cellular imaging
  • Crystal structure
  • Iron
  • Photocytotoxicity
  • Salicylic acid

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