Iron metabolism and ineffective erythropoiesis in β-thalassemia mouse models

Pedro Ramos, Luca Melchiori, Sara Gardenghi, Nico Van-Roijen, Robert W. Grady, Yelena Ginzburg, Stefano Rivella

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

17 Scopus citations


β-thalassemia is a disease associated with decreased β-globin production leading to anemia, ineffective erythropoiesis, and iron overload. New mechanisms associated with modulation of erythropoiesis and iron metabolism have recently been discovered in thalassemic mice, improving our understanding of the pathophysiology of this disease. These discoveries have the potential to be translated into clinically-relevant therapeutic options to reduce ineffective erythropoiesis and iron overload. A new generation of therapies based on limiting ineffective erythropoiesis, iron absorption, and the correction of iron maldistribution could be on the way, possibly complementing and improving the current standard of patient care.

Original languageEnglish
Title of host publicationCooley's Anemia
Subtitle of host publicationNinth Symposium
PublisherBlackwell Publishing Inc.
Number of pages7
ISBN (Print)9781573317825
StatePublished - Aug 2010
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Jak2
  • hepcidin
  • ineffective erythropoiesis
  • iron overload
  • transferrin
  • β-thalassemia


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