@inproceedings{47739577eafa44f6b477a09093e7c0b1,
title = "Iron metabolism and ineffective erythropoiesis in β-thalassemia mouse models",
abstract = "β-thalassemia is a disease associated with decreased β-globin production leading to anemia, ineffective erythropoiesis, and iron overload. New mechanisms associated with modulation of erythropoiesis and iron metabolism have recently been discovered in thalassemic mice, improving our understanding of the pathophysiology of this disease. These discoveries have the potential to be translated into clinically-relevant therapeutic options to reduce ineffective erythropoiesis and iron overload. A new generation of therapies based on limiting ineffective erythropoiesis, iron absorption, and the correction of iron maldistribution could be on the way, possibly complementing and improving the current standard of patient care.",
keywords = "Jak2, hepcidin, ineffective erythropoiesis, iron overload, transferrin, β-thalassemia",
author = "Pedro Ramos and Luca Melchiori and Sara Gardenghi and Nico Van-Roijen and Grady, {Robert W.} and Yelena Ginzburg and Stefano Rivella",
year = "2010",
month = aug,
doi = "10.1111/j.1749-6632.2010.05596.x",
language = "English",
isbn = "9781573317825",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "24--30",
booktitle = "Cooley's Anemia",
}