TY - JOUR
T1 - Ionic Flux Across the Gastric Mucosa
T2 - Effects of Atropine on the Permeability of Fundus and Antrum 35104
AU - Rudick, Jack
AU - Werther, J. Lawrence
AU - Chapman, Mark L.
AU - Janowitz, Henry D.
PY - 1970/12
Y1 - 1970/12
N2 - The effects of atropine were evaluated on ionic movement across fundic and antral mucosa. 0.16 N HCl solutions were instilled into vagally denervated fundic and antral pouches. Atropine 0.05 mg/kg increased the mean net loss of H+ ions in both pouches, but to a slightly greater extent in the fundus 86% than in the antrum 66%). Although the mechanism of action is speculative, it is suggested that the diminished acid output in gastric secretion following atropine may be due to secretory inhibition, and to a lesser extent, a transmucosal loss of hydrogen ions.
AB - The effects of atropine were evaluated on ionic movement across fundic and antral mucosa. 0.16 N HCl solutions were instilled into vagally denervated fundic and antral pouches. Atropine 0.05 mg/kg increased the mean net loss of H+ ions in both pouches, but to a slightly greater extent in the fundus 86% than in the antrum 66%). Although the mechanism of action is speculative, it is suggested that the diminished acid output in gastric secretion following atropine may be due to secretory inhibition, and to a lesser extent, a transmucosal loss of hydrogen ions.
UR - http://www.scopus.com/inward/record.url?scp=0014897310&partnerID=8YFLogxK
U2 - 10.3181/00379727-135-35104
DO - 10.3181/00379727-135-35104
M3 - Article
C2 - 5486691
AN - SCOPUS:0014897310
SN - 0037-9727
VL - 135
SP - 605
EP - 608
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 3
ER -