Investigations concerning the cellular origin of dopamine receptors

F. A. Henn; M. Titeler; D. J. Anderson; K. May

doi:10.1016/0024-3205(78)90042-5

Investigations concerning the cellular origin of dopamine receptors

F. A. Henn, M. Titeler, D. J. Anderson, K. May

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Abstract

The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of [³H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors.

Original language	English
Pages (from-to)	617-621
Number of pages	5
Journal	Life Sciences
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(78)90042-5
State	Published - 14 Aug 1978
Externally published	Yes

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title = "Investigations concerning the cellular origin of dopamine receptors",

abstract = "The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of [3H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors.",

author = "Henn, {F. A.} and M. Titeler and Anderson, {D. J.} and K. May",

year = "1978",

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doi = "10.1016/0024-3205(78)90042-5",

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AU - Henn, F. A.

AU - Titeler, M.

AU - Anderson, D. J.

AU - May, K.

PY - 1978/8/14

Y1 - 1978/8/14

N2 - The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of [3H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors.

AB - The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of [3H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors.

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U2 - 10.1016/0024-3205(78)90042-5

DO - 10.1016/0024-3205(78)90042-5

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AN - SCOPUS:0018075491

SN - 0024-3205

VL - 23

SP - 617

EP - 621

JO - Life Sciences

JF - Life Sciences

IS - 6

ER -

Investigations concerning the cellular origin of dopamine receptors

Abstract

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