Investigations concerning the cellular origin of dopamine receptors

F. A. Henn, M. Titeler, D. J. Anderson, K. May

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of [3H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors.

Original languageEnglish
Pages (from-to)617-621
Number of pages5
JournalLife Sciences
Issue number6
StatePublished - 14 Aug 1978
Externally publishedYes


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