Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder

Sîan M.J. Hemmings; Craig J. Kinnear; Dana J.H. Niehaus; Johanna C. Moolman-Smook; Christine Lochner; James A. Knowles; Valerie A. Corfield; Dan J. Stein

doi:10.1016/S0924-977X(02)00129-3

Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder

Sîan M.J. Hemmings, Craig J. Kinnear, Dana J.H. Niehaus, Johanna C. Moolman-Smook, Christine Lochner, James A. Knowles, Valerie A. Corfield, Dan J. Stein

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

There is increasing evidence that the aetiology of obsessive-compulsive disorder (OCD) has a marked genetic component, although the precise mechanism of inheritance is unclear. Clinical and pharmacological studies have implicated the serotonergic and dopaminergic systems in disease pathogenesis. This study investigated the role of attractive candidate genes in the serotonergic and dopaminergic pathways in the development of OCD. The distribution of selected polymorphic variants in the serotonin receptor type 2A and 1Dβ (5-HT_2A, 5-HT_1Dβ), dopamine transporter (DAT), dopamine receptor type 4 (DRD4) and monoamine-oxidase A (MAO-A) genes were analysed in 71 OCD cases and 129 control individuals in the genetically homogeneous Afrikaner population, by means of case-control association studies. Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation.

Original language	English
Pages (from-to)	93-98
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/S0924-977X(02)00129-3
State	Published - Mar 2003
Externally published	Yes

Keywords

Afrikaner
Association studies
Genetics
Obsessive-compulsive disorder

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10.1016/S0924-977X(02)00129-3

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title = "Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder",

abstract = "There is increasing evidence that the aetiology of obsessive-compulsive disorder (OCD) has a marked genetic component, although the precise mechanism of inheritance is unclear. Clinical and pharmacological studies have implicated the serotonergic and dopaminergic systems in disease pathogenesis. This study investigated the role of attractive candidate genes in the serotonergic and dopaminergic pathways in the development of OCD. The distribution of selected polymorphic variants in the serotonin receptor type 2A and 1Dβ (5-HT2A, 5-HT1Dβ), dopamine transporter (DAT), dopamine receptor type 4 (DRD4) and monoamine-oxidase A (MAO-A) genes were analysed in 71 OCD cases and 129 control individuals in the genetically homogeneous Afrikaner population, by means of case-control association studies. Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation.",

keywords = "Afrikaner, Association studies, Genetics, Obsessive-compulsive disorder",

author = "Hemmings, {S{\^i}an M.J.} and Kinnear, {Craig J.} and Niehaus, {Dana J.H.} and Moolman-Smook, {Johanna C.} and Christine Lochner and Knowles, {James A.} and Corfield, {Valerie A.} and Stein, {Dan J.}",

note = "Funding Information: This work is supported by grants from the Medical Research Council (MRC) (SH), the National Research Foundation (CK), Harry and Dorris Crossley (SH, CK) and the Obsessive-Compulsive Foundation (Drs. Stein and Knowles). The Obsessive-Compulsive Association (OCA) of South Africa played a crucial role in the undertaking of this work. ",

year = "2003",

month = mar,

doi = "10.1016/S0924-977X(02)00129-3",

language = "English",

volume = "13",

pages = "93--98",

journal = "European Neuropsychopharmacology",

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T1 - Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder

AU - Hemmings, Sîan M.J.

AU - Kinnear, Craig J.

AU - Niehaus, Dana J.H.

AU - Moolman-Smook, Johanna C.

AU - Lochner, Christine

AU - Knowles, James A.

AU - Corfield, Valerie A.

AU - Stein, Dan J.

N1 - Funding Information: This work is supported by grants from the Medical Research Council (MRC) (SH), the National Research Foundation (CK), Harry and Dorris Crossley (SH, CK) and the Obsessive-Compulsive Foundation (Drs. Stein and Knowles). The Obsessive-Compulsive Association (OCA) of South Africa played a crucial role in the undertaking of this work.

PY - 2003/3

Y1 - 2003/3

N2 - There is increasing evidence that the aetiology of obsessive-compulsive disorder (OCD) has a marked genetic component, although the precise mechanism of inheritance is unclear. Clinical and pharmacological studies have implicated the serotonergic and dopaminergic systems in disease pathogenesis. This study investigated the role of attractive candidate genes in the serotonergic and dopaminergic pathways in the development of OCD. The distribution of selected polymorphic variants in the serotonin receptor type 2A and 1Dβ (5-HT2A, 5-HT1Dβ), dopamine transporter (DAT), dopamine receptor type 4 (DRD4) and monoamine-oxidase A (MAO-A) genes were analysed in 71 OCD cases and 129 control individuals in the genetically homogeneous Afrikaner population, by means of case-control association studies. Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation.

AB - There is increasing evidence that the aetiology of obsessive-compulsive disorder (OCD) has a marked genetic component, although the precise mechanism of inheritance is unclear. Clinical and pharmacological studies have implicated the serotonergic and dopaminergic systems in disease pathogenesis. This study investigated the role of attractive candidate genes in the serotonergic and dopaminergic pathways in the development of OCD. The distribution of selected polymorphic variants in the serotonin receptor type 2A and 1Dβ (5-HT2A, 5-HT1Dβ), dopamine transporter (DAT), dopamine receptor type 4 (DRD4) and monoamine-oxidase A (MAO-A) genes were analysed in 71 OCD cases and 129 control individuals in the genetically homogeneous Afrikaner population, by means of case-control association studies. Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation.

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KW - Association studies

KW - Genetics

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DO - 10.1016/S0924-977X(02)00129-3

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Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder

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Keywords

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