TY - JOUR
T1 - Investigating Motor Preparation in Autism Spectrum Disorder With and Without Attention Deficit/Hyperactivity Disorder
AU - Migó, Marta
AU - Guillory, Sylvia B.
AU - McLaughlin, Christopher S.
AU - Isenstein, Emily L.
AU - Grosman, Hannah E.
AU - Thakkar, Katharine N.
AU - Castellanos, Francisco X.
AU - Foss-Feig, Jennifer H.
N1 - Funding Information:
This research was supported in part by the National Center for Advancing Translational Sciences TL1TR001434 (SBG), the National Institute of Mental Health Grant R21MH115297 (JHF, KNT), the Seaver Foundation (JHF), and New York University’s Dean’s Undergraduate Research Fund (MM).
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/6
Y1 - 2022/6
N2 - This study investigated motor preparation and action-consequence prediction using the lateralized readiness potential (LRP). Motor impairments are common in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. Alterations in predictive processes may impact motor planning. Whether motor planning deficits are characteristic of ASD broadly or magnified in the context of co-morbid ADHD is unclear. ASD children with (ASD + ADHD; n = 12) and without (ASD − ADHD; n = 9) comorbid ADHD and typical controls (n = 29) performed voluntary motor actions that either did or did not result in auditory consequences. ASD − ADHD children demonstrated LRP enhancement when their action produced an effect while ASD + ADHD children had attenuated responses regardless of action-effect pairings. Findings suggest influence of ADHD comorbidity on motor preparation and prediction in ASD.
AB - This study investigated motor preparation and action-consequence prediction using the lateralized readiness potential (LRP). Motor impairments are common in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), which commonly co-occur. Alterations in predictive processes may impact motor planning. Whether motor planning deficits are characteristic of ASD broadly or magnified in the context of co-morbid ADHD is unclear. ASD children with (ASD + ADHD; n = 12) and without (ASD − ADHD; n = 9) comorbid ADHD and typical controls (n = 29) performed voluntary motor actions that either did or did not result in auditory consequences. ASD − ADHD children demonstrated LRP enhancement when their action produced an effect while ASD + ADHD children had attenuated responses regardless of action-effect pairings. Findings suggest influence of ADHD comorbidity on motor preparation and prediction in ASD.
KW - Attention-deficit/hyperactivity disorder (ADHD)
KW - Autism spectrum disorder (ASD)
KW - EEG
KW - Lateralized readiness potential (LRP)
KW - Motor preparation
KW - Prediction
UR - http://www.scopus.com/inward/record.url?scp=85108597042&partnerID=8YFLogxK
U2 - 10.1007/s10803-021-05130-5
DO - 10.1007/s10803-021-05130-5
M3 - Article
C2 - 34160725
AN - SCOPUS:85108597042
SN - 0162-3257
VL - 52
SP - 2379
EP - 2387
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 6
ER -