Investigating Lipid-Modulating Agents for Prevention or Treatment of COVID-19: JACC State-of-the-Art Review

Azita H. Talasaz, Parham Sadeghipour, Maryam Aghakouchakzadeh, Isaac Dreyfus, Hessam Kakavand, Hamid Ariannejad, Aakriti Gupta, Mahesh V. Madhavan, Benjamin W. Van Tassell, David Jimenez, Manuel Monreal, Muthiah Vaduganathan, John Fanikos, Dave L. Dixon, Gregory Piazza, Sahil A. Parikh, Deepak L. Bhatt, Gregory Y.H. Lip, Gregg W. Stone, Harlan M. KrumholzPeter Libby, Samuel Z. Goldhaber, Behnood Bikdeli

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Coronavirus disease-2019 (COVID-19) is associated with systemic inflammation, endothelial activation, and multiorgan manifestations. Lipid-modulating agents may be useful in treating patients with COVID-19. These agents may inhibit viral entry by lipid raft disruption or ameliorate the inflammatory response and endothelial activation. In addition, dyslipidemia with lower high-density lipoprotein cholesterol and higher triglyceride levels portend worse outcomes in patients with COVID-19. Upon a systematic search, 40 randomized controlled trials (RCTs) with lipid-modulating agents were identified, including 17 statin trials, 14 omega-3 fatty acids RCTs, 3 fibrate RCTs, 5 niacin RCTs, and 1 dalcetrapib RCT for the management or prevention of COVID-19. From these 40 RCTs, only 2 have reported preliminary results, and most others are ongoing. This paper summarizes the ongoing or completed RCTs of lipid-modulating agents in COVID-19 and the implications of these trials for patient management.

Original languageEnglish
Pages (from-to)1635-1654
Number of pages20
JournalJournal of the American College of Cardiology
Issue number16
StatePublished - 19 Oct 2021


  • COVID-19
  • fibrate
  • lipid-modulating agent
  • niacin
  • omega-3
  • statin


Dive into the research topics of 'Investigating Lipid-Modulating Agents for Prevention or Treatment of COVID-19: JACC State-of-the-Art Review'. Together they form a unique fingerprint.

Cite this