Invasive cortical stimulation

Richard Ogbuji, Brian Harris Kopell

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The field of neuromodulation, at its essence, aims to apply electrical stimulation to the brain to ameliorate various pathology. Many methods of applying this stimulation exist, including invasive and non-invasive means. In the realm of invasive stimulation, stimulation of the cortex remains one of the earliest techniques investigated, yet one of the most underutilized today. Evidence for the efficacy of direct invasive cortical stimulation continues to mount, especially in recent years. In this chapter we will review the evidence for the use of invasive cortical stimulation as it applies to neuropathic pain, epilepsy, psychiatric disease, movement disorders, tinnitus, and post-stroke recovery, as well explore some potential mechanisms and future directions of the technique.

Original languageEnglish
Title of host publicationEmerging Horizons in Neuromodulation
Subtitle of host publicationNew Frontiers in Brain and Spine Stimulation
EditorsElena Moro, Mircea Polosan, Clement Hamani
PublisherAcademic Press Inc.
Number of pages23
ISBN (Print)9780128222980
StatePublished - Jan 2021

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742
ISSN (Electronic)2162-5514


  • Epicranial stimulation
  • Epilepsy
  • Invasive cortical stimulation
  • Movement disorders
  • Neuromodulation
  • Neuropathic pain
  • Post-stroke rehabilitation
  • Psychiatric disease
  • Review
  • Tinnitus


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