TY - JOUR
T1 - Intrusive thoughts and quality of life among men with prostate cancer before and three months after surgery
AU - Thorsteinsdottir, Thordis
AU - Hedelin, Maria
AU - Stranne, Johan
AU - Valdimarsdóttir, Heiddis
AU - Wilderäng, Ulrica
AU - Haglind, Eva
AU - Steineck, Gunnar
N1 - Funding Information:
The authors gratefully acknowledge the participants in the LAPPRO trial, the members of the steering committee, the investigators at the participating hospitals, and the personnel at the trial secretariat for their provision of study material and administrative support. Further acknowledgements to the Swedish Cancer Society (CAN2008/922, CAN2009/1099, CAN2010/593), Region Västra Götaland, Sahlgrenska University Hospital (VGR 27551, 79291, 152231; ALF grants 11573, 138751 and 146201, HTA – VGR grant 6011 agreement concerning research and education of doctors), Swedish Research Council, Mrs Mary von Sydow Foundation and Anna and Edvin Berger foundation, all non-profit organizations, which supported the LAPPRO trial financially.
PY - 2013/9/11
Y1 - 2013/9/11
N2 - Background: Sudden, unwelcome and repetitive thoughts about a traumatic event - intrusive thoughts - could relate to how men assess their quality of life after prostate-cancer diagnosis. We aimed to study the prevalence of intrusive thoughts about prostate cancer and their association with quality-of-life outcomes before and after radical prostatectomy.Methods: During the first year of the LAPPRO-trial, 971 men scheduled for radical prostatectomy were prospectively included from 14 urological centers in Sweden. Of those, 833 men responded to two consecutive study-specific questionnaires before and three months after surgery (participation rate 86%). The association of intrusive thoughts with three quality-of-life outcomes, i.e. self-assessed quality of life, depressive mood and waking up with anxiety was estimated by prevalence ratios that were calculated, together with a 95% confidence interval, at the same time-point as well as over time. Fisher's exact-test was used to analyze differences between respondents and non-respondents. Wilcoxon signed-ranks and Cochran-Armitage trend tests were used for analysis of change over time. To validate new questions on intrusive thoughts, written answers to open-ended questions were read and analyzed by qualitative content analysis.Results: Before surgery, 603 men (73%) reported negative intrusive thoughts about their cancer at some time in the past month and 593 men (59%) reported such thoughts three months after surgery. Comparing those reporting intrusive thoughts at least weekly or once a week before surgery with those who did not, the prevalence ratio (95% confidence interval), three months after surgery, for waking up in the middle of the night with anxiety was 3.9 (2.7 to 5.5), for depressed mood 1.8 (1.6 to 2.1) and for impaired self-assessed quality of life 1.3 (1.2 to 1.5).Conclusion: The prevalence of negative intrusive thoughts about prostate cancer at the time of surgery associates with studied quality-of-life outcomes three months later.Trial registration: Current Controlled Trials, ISRCTN06393679.
AB - Background: Sudden, unwelcome and repetitive thoughts about a traumatic event - intrusive thoughts - could relate to how men assess their quality of life after prostate-cancer diagnosis. We aimed to study the prevalence of intrusive thoughts about prostate cancer and their association with quality-of-life outcomes before and after radical prostatectomy.Methods: During the first year of the LAPPRO-trial, 971 men scheduled for radical prostatectomy were prospectively included from 14 urological centers in Sweden. Of those, 833 men responded to two consecutive study-specific questionnaires before and three months after surgery (participation rate 86%). The association of intrusive thoughts with three quality-of-life outcomes, i.e. self-assessed quality of life, depressive mood and waking up with anxiety was estimated by prevalence ratios that were calculated, together with a 95% confidence interval, at the same time-point as well as over time. Fisher's exact-test was used to analyze differences between respondents and non-respondents. Wilcoxon signed-ranks and Cochran-Armitage trend tests were used for analysis of change over time. To validate new questions on intrusive thoughts, written answers to open-ended questions were read and analyzed by qualitative content analysis.Results: Before surgery, 603 men (73%) reported negative intrusive thoughts about their cancer at some time in the past month and 593 men (59%) reported such thoughts three months after surgery. Comparing those reporting intrusive thoughts at least weekly or once a week before surgery with those who did not, the prevalence ratio (95% confidence interval), three months after surgery, for waking up in the middle of the night with anxiety was 3.9 (2.7 to 5.5), for depressed mood 1.8 (1.6 to 2.1) and for impaired self-assessed quality of life 1.3 (1.2 to 1.5).Conclusion: The prevalence of negative intrusive thoughts about prostate cancer at the time of surgery associates with studied quality-of-life outcomes three months later.Trial registration: Current Controlled Trials, ISRCTN06393679.
KW - Clinical trial
KW - Intrusive thoughts
KW - Prostate cancer
KW - Quality of life
UR - https://www.scopus.com/pages/publications/84883606707
U2 - 10.1186/1477-7525-11-154
DO - 10.1186/1477-7525-11-154
M3 - Article
C2 - 24025241
AN - SCOPUS:84883606707
SN - 1477-7525
VL - 11
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
IS - 1
M1 - 154
ER -