TY - JOUR
T1 - Introductions and early spread of SARS-CoV-2 in the New York City area
AU - Gonzalez-Reiche, Ana S.
AU - Hernandez, Matthew M.
AU - Sullivan, Mitchell J.
AU - Ciferri, Brianne
AU - Alshammary, Hala
AU - Obla, Ajay
AU - Fabre, Shelcie
AU - Kleiner, Giulio
AU - Polanco, Jose
AU - Khan, Zenab
AU - Alburquerque, Bremy
AU - van de Guchte, Adriana
AU - Dutta, Jayeeta
AU - Francoeur, Nancy
AU - Melo, Betsaida Salom
AU - Oussenko, Irina
AU - Deikus, Gintaras
AU - Soto, Juan
AU - Sridhar, Shwetha Hara
AU - Wang, Ying Chih
AU - Twyman, Kathryn
AU - Kasarskis, Andrew
AU - Altman, Deena R.
AU - Smith, Melissa
AU - Sebra, Robert
AU - Aberg, Judith
AU - Krammer, Florian
AU - García-Sastre, Adolfo
AU - Luksza, Marta
AU - Patel, Gopi
AU - Paniz-Mondolfi, Alberto
AU - Gitman, Melissa
AU - Sordillo, Emilia Mia
AU - Simon, Viviana
AU - van Bakel, Harm
N1 - Publisher Copyright:
© 2020 American Association for the Advancement of Science. All rights reserved.
PY - 2020/7/17
Y1 - 2020/7/17
N2 - New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.
AB - New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.
UR - http://www.scopus.com/inward/record.url?scp=85088243882&partnerID=8YFLogxK
U2 - 10.1126/science.abc1917
DO - 10.1126/science.abc1917
M3 - Article
C2 - 32471856
AN - SCOPUS:85088243882
SN - 0036-8075
VL - 369
SP - 297
EP - 301
JO - Science
JF - Science
IS - 6501
ER -