Introductions and early spread of SARS-CoV-2 in the New York City area

Ana S. Gonzalez-Reiche; Matthew M. Hernandez; Mitchell J. Sullivan; Brianne Ciferri; Hala Alshammary; Ajay Obla; Shelcie Fabre; Giulio Kleiner; Jose Polanco; Zenab Khan; Bremy Alburquerque; Adriana van de Guchte; Jayeeta Dutta; Nancy Francoeur; Betsaida Salom Melo; Irina Oussenko; Gintaras Deikus; Juan Soto; Shwetha Hara Sridhar; Ying Chih Wang; Kathryn Twyman; Andrew Kasarskis; Deena R. Altman; Melissa Smith; Robert Sebra; Judith Aberg; Florian Krammer; Adolfo García-Sastre; Marta Luksza; Gopi Patel; Alberto Paniz-Mondolfi; Melissa Gitman; Emilia Mia Sordillo; Viviana Simon; Harm van Bakel

doi:10.1126/science.abc1917

Introductions and early spread of SARS-CoV-2 in the New York City area

Ana S. Gonzalez-Reiche, Matthew M. Hernandez, Mitchell J. Sullivan, Brianne Ciferri, Hala Alshammary, Ajay Obla, Shelcie Fabre, Giulio Kleiner, Jose Polanco, Zenab Khan, Bremy Alburquerque, Adriana van de Guchte, Jayeeta Dutta, Nancy Francoeur, Betsaida Salom Melo, Irina Oussenko, Gintaras Deikus, Juan Soto, Shwetha Hara Sridhar, Ying Chih WangKathryn Twyman, Andrew Kasarskis, Deena R. Altman, Melissa Smith, Robert Sebra, Judith Aberg, Florian Krammer, Adolfo García-Sastre, Marta Luksza, Gopi Patel, Alberto Paniz-Mondolfi, Melissa Gitman, Emilia Mia Sordillo, Viviana Simon, Harm van Bakel

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236 Scopus citations

Abstract

New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.

Original language	English
Pages (from-to)	297-301
Number of pages	5
Journal	Science
Volume	369
Issue number	6501
DOIs	https://doi.org/10.1126/science.abc1917
State	Published - 17 Jul 2020

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Gonzalez-Reiche, A. S., Hernandez, M. M., Sullivan, M. J., Ciferri, B., Alshammary, H., Obla, A., Fabre, S., Kleiner, G., Polanco, J., Khan, Z., Alburquerque, B., van de Guchte, A., Dutta, J., Francoeur, N., Melo, B. S., Oussenko, I., Deikus, G., Soto, J., Sridhar, S. H., ... van Bakel, H. (2020). Introductions and early spread of SARS-CoV-2 in the New York City area. Science, 369(6501), 297-301. https://doi.org/10.1126/science.abc1917

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title = "Introductions and early spread of SARS-CoV-2 in the New York City area",

abstract = "New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.",

author = "Gonzalez-Reiche, {Ana S.} and Hernandez, {Matthew M.} and Sullivan, {Mitchell J.} and Brianne Ciferri and Hala Alshammary and Ajay Obla and Shelcie Fabre and Giulio Kleiner and Jose Polanco and Zenab Khan and Bremy Alburquerque and {van de Guchte}, Adriana and Jayeeta Dutta and Nancy Francoeur and Melo, {Betsaida Salom} and Irina Oussenko and Gintaras Deikus and Juan Soto and Sridhar, {Shwetha Hara} and Wang, {Ying Chih} and Kathryn Twyman and Andrew Kasarskis and Altman, {Deena R.} and Melissa Smith and Robert Sebra and Judith Aberg and Florian Krammer and Adolfo Garc{\'i}a-Sastre and Marta Luksza and Gopi Patel and Alberto Paniz-Mondolfi and Melissa Gitman and Sordillo, {Emilia Mia} and Viviana Simon and {van Bakel}, Harm",

year = "2020",

month = jul,

day = "17",

doi = "10.1126/science.abc1917",

language = "English",

volume = "369",

pages = "297--301",

journal = "Science",

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Gonzalez-Reiche, AS, Hernandez, MM, Sullivan, MJ, Ciferri, B, Alshammary, H, Obla, A, Fabre, S, Kleiner, G, Polanco, J, Khan, Z, Alburquerque, B, van de Guchte, A, Dutta, J, Francoeur, N, Melo, BS, Oussenko, I, Deikus, G, Soto, J, Sridhar, SH, Wang, YC, Twyman, K, Kasarskis, A , Altman, DR, Smith, M, Sebra, R , Aberg, J , Krammer, F , García-Sastre, A , Luksza, M , Patel, G, Paniz-Mondolfi, A, Gitman, M, Sordillo, EM , Simon, V & van Bakel, H 2020, 'Introductions and early spread of SARS-CoV-2 in the New York City area', Science, vol. 369, no. 6501, pp. 297-301. https://doi.org/10.1126/science.abc1917

TY - JOUR

T1 - Introductions and early spread of SARS-CoV-2 in the New York City area

AU - Gonzalez-Reiche, Ana S.

AU - Hernandez, Matthew M.

AU - Sullivan, Mitchell J.

AU - Ciferri, Brianne

AU - Alshammary, Hala

AU - Obla, Ajay

AU - Fabre, Shelcie

AU - Kleiner, Giulio

AU - Polanco, Jose

AU - Khan, Zenab

AU - Alburquerque, Bremy

AU - van de Guchte, Adriana

AU - Dutta, Jayeeta

AU - Francoeur, Nancy

AU - Melo, Betsaida Salom

AU - Oussenko, Irina

AU - Deikus, Gintaras

AU - Soto, Juan

AU - Sridhar, Shwetha Hara

AU - Wang, Ying Chih

AU - Twyman, Kathryn

AU - Kasarskis, Andrew

AU - Altman, Deena R.

AU - Smith, Melissa

AU - Sebra, Robert

AU - Aberg, Judith

AU - Krammer, Florian

AU - García-Sastre, Adolfo

AU - Luksza, Marta

AU - Patel, Gopi

AU - Paniz-Mondolfi, Alberto

AU - Gitman, Melissa

AU - Sordillo, Emilia Mia

AU - Simon, Viviana

AU - van Bakel, Harm

PY - 2020/7/17

Y1 - 2020/7/17

N2 - New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.

AB - New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.

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U2 - 10.1126/science.abc1917

DO - 10.1126/science.abc1917

M3 - Article

C2 - 32471856

AN - SCOPUS:85088243882

SN - 0036-8075

VL - 369

SP - 297

EP - 301

JO - Science

JF - Science

IS - 6501

ER -

Introductions and early spread of SARS-CoV-2 in the New York City area

Abstract

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