Introducing pharmacogenomic decision support for medication risk assessment in people with polypharmacy

Jiazhen Liu, Joseph Finkelstein

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Polypharmacy has been shown to be a source of multiple adverse drug events. Recent studies demonstrated that pharmacogenomic testing may be instrumental in optimizing medication regimen. However, majority of current pharmacogenomic decision support tools provide assessment only of single drug-gene interactions without taking into account complex drug-drug and drug-drug-gene interactions which are prevalent in people with polypharmacy and were shown to be a significant source of adverse drug events. The main objective of this project is development of comprehensive pharmacogenomic decision support for medication risk assessment in people with polypharmacy. To achieve this goal, the project addressed two aims: (1) development of comprehensive knowledge repository of actionable pharmacogenes; (2) introduction of scoring approaches reflecting potential adverse effect risk levels of complex medication regimens accounting for pharmacogenomic polymorphisms and multiple drug metabolizing pathways. After pharmacogenomic knowledge repository was introduced, additive and multiplicative algorithms for medication risk assessment have been implemented. An initial prototype assessment demonstrated feasibility of our approach and identified steps for improving risk scoring algorithms.

Original languageEnglish
Title of host publicationProceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
EditorsIllhoi Yoo, Jane Huiru Zheng, Yang Gong, Xiaohua Tony Hu, Chi-Ren Shyu, Yana Bromberg, Jean Gao, Dmitry Korkin
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1803-1808
Number of pages6
ISBN (Electronic)9781509030491
DOIs
StatePublished - 15 Dec 2017
Externally publishedYes
Event2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017 - Kansas City, United States
Duration: 13 Nov 201716 Nov 2017

Publication series

NameProceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
Volume2017-January

Conference

Conference2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017
Country/TerritoryUnited States
CityKansas City
Period13/11/1716/11/17

Keywords

  • adverse drug events
  • decision support
  • pharmacogenomics
  • polypharmacy

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