Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Ana M.G. Manea, Anna Zilverstand, Kamil Ugurbil, Sarah R. Heilbronner, Jan Zimmermann

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field functional magnetic resonance imaging (fMRI) performed at 10.5 T to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we extended existing electrophysiological hierarchies to whole-brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Further, with these results in hand, we were able to show that one facet of the high-dimensional functional connectivity (FC) topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match FC gradient topographies across the whole brain. We conclude that intrinsic timescales are a unifying organizational principle of neural processing across the whole brain.

Original languageEnglish
Article numbere75540
JournaleLife
Volume11
DOIs
StatePublished - Mar 2022
Externally publishedYes

Fingerprint

Dive into the research topics of 'Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain'. Together they form a unique fingerprint.

Cite this