Intravesical BCG treatment causes a long-lasting reduction of recurrence and progression in patients with high-risk non-muscle-invasive bladder cancer

Tomas Thiel, Charlotta Ryk, Lotta Renström-Koskela, Gunnar Steineck, Martin C. Schumacher, N. Peter Wiklund, Petra J. de Verdier

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Purpose: To analyse if BCG treatment leads to long-term reduction of recurrence, progression, and cancer-specific mortality (CSM) in patients with high-risk NMIBC. Materials and methods: 140 patients with high-risk NMIBC were drawn from a population-based cohort of 538 patients with newly diagnosed bladder cancer in the Stockholm County between 1995 and 1996. Data were collected prospectively, and a final follow-up for recurrence, progression, and CSM was performed after 15 years. Patients that received BCG were compared with patients who did not receive BCG. Survival analysis was done with Kaplan–Meier estimates and Mantel–Cox log-rank test. Multivariable Cox proportional regression with stepwise selection was performed to verify the statistical significance of clinicopathological factors of prognostic importance. Results were displayed in Hazard ratios and a p < 0.05 was considered to be statistically significant. Results: With a median follow-up of 100 months (2–182), 76 patients recurred; 50 progressed to muscle invasion; and 92 died of whom 38 died from bladder cancer. After 15-year follow-up, there was a statistically significant reduction in rate for recurrence (HR 0.40, p < 0.0001) and progression (HR 0.52, p = 0.038), but not for CSM, in patients that received BCG compared to those who did not. Conclusions: In this group, BCG in high-risk NMIBC patients reduced the long-term risk of recurrence and progression. The effect on CSM is yet to be clarified.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalWorld Journal of Urology
Volume37
Issue number1
DOIs
StatePublished - 23 Jan 2019
Externally publishedYes

Keywords

  • BCG
  • Non-muscle-invasive bladder cancer
  • Progression
  • Recurrence
  • Survival

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