Intravenous dantrolene in a patient with myasthenia gravis

C. T. Mora; J. B. Eisenkraft; A. E. Papatestas

doi:10.1097/00000542-198603000-00014

Intravenous dantrolene in a patient with myasthenia gravis

C. T. Mora, J. B. Eisenkraft, A. E. Papatestas

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Abstract

We report a case in which dantrolene administered in a dose sufficient to provide prophylaxis for MH, was safely administered to a patient with generalized MG. The responses to dantrolene in our MG patient differed from those in healthy volunteers. Specifically, our patient was resistant to the twitch-depressant effects of dantrolene, but after 2-3 h demonstrated a significant decrease in fade ratio. While dantrolene may produce clinical improvement in rats with EAMG, further studies would be required to determine whether it has a similar effect in human MG.

Original language	English
Pages (from-to)	371-373
Number of pages	3
Journal	Anesthesiology
Volume	64
Issue number	3
DOIs	https://doi.org/10.1097/00000542-198603000-00014
State	Published - 1986
Externally published	Yes

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title = "Intravenous dantrolene in a patient with myasthenia gravis",

abstract = "We report a case in which dantrolene administered in a dose sufficient to provide prophylaxis for MH, was safely administered to a patient with generalized MG. The responses to dantrolene in our MG patient differed from those in healthy volunteers. Specifically, our patient was resistant to the twitch-depressant effects of dantrolene, but after 2-3 h demonstrated a significant decrease in fade ratio. While dantrolene may produce clinical improvement in rats with EAMG, further studies would be required to determine whether it has a similar effect in human MG.",

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year = "1986",

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AU - Eisenkraft, J. B.

AU - Papatestas, A. E.

PY - 1986

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AB - We report a case in which dantrolene administered in a dose sufficient to provide prophylaxis for MH, was safely administered to a patient with generalized MG. The responses to dantrolene in our MG patient differed from those in healthy volunteers. Specifically, our patient was resistant to the twitch-depressant effects of dantrolene, but after 2-3 h demonstrated a significant decrease in fade ratio. While dantrolene may produce clinical improvement in rats with EAMG, further studies would be required to determine whether it has a similar effect in human MG.

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ER -

Intravenous dantrolene in a patient with myasthenia gravis

Abstract

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