Intrauterine growth restriction in twin pregnancies: Incidence and associated risk factors

Nathan S. Fox, Andrei Rebarber, Chad K. Klauser, Ashley S. Roman, Daniel H. Saltzman

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

We sought to estimate the association of several maternal risk factors with intrauterine growth restriction (IUGR) in twin pregnancies. This is a case-control study of 313 patients with twin pregnancies delivered greater than 24 weeks between June 2005 and January 2010. We used three definitions of IUGR: (1) either twin with a birth weight < 10th percentile for gestational age; (2) either twin with a birth weight < 5th percentile for gestational age; and (3) birth-weight discordance 20%. Using each definition of IUGR, we estimated the association between IUGR and maternal age, weight, monochorionicity, in vitro fertilization, pregnancy reduction, thrombophilia, hypertension, and diabetes. Overall, 47% of patients delivered at least one twin with a birth weight <10th percentile, 27% of patients delivered at least one twin with a birth weight <5th percentile, and 16% of patients had birth-weight discordance of 20%. Using any of these three definitions for IUGR in twin pregnancies, there was no significant association between IUGR and any of the risk factors examined. This remained true when we excluded all patients who delivered <34 weeks. IUGR is very common in twin pregnancies. However, in twin pregnancies, IUGR cannot be predicted by maternal risk factors.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalAmerican Journal of Perinatology
Volume28
Issue number4
DOIs
StatePublished - 2011

Keywords

  • IUGR
  • Twins
  • incidence
  • prediction

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