Intraoperative Imaging and Optical Visualization Techniques for Brain Tumor Resection: A Narrative Review

Othman Bin-Alamer, Hussam Abou-Al-Shaar, Zachary C. Gersey, Sakibul Huq, Justiss A. Kallos, David J. McCarthy, Jeffery R. Head, Edward Andrews, Xiaoran Zhang, Constantinos G. Hadjipanayis

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Advancements in intraoperative visualization and imaging techniques are increasingly central to the success and safety of brain tumor surgery, leading to transformative improvements in patient outcomes. This comprehensive review intricately describes the evolution of conventional and emerging technologies for intraoperative imaging, encompassing the surgical microscope, exoscope, Raman spectroscopy, confocal microscopy, fluorescence-guided surgery, intraoperative ultrasound, magnetic resonance imaging, and computed tomography. We detail how each of these imaging modalities contributes uniquely to the precision, safety, and efficacy of neurosurgical procedures. Despite their substantial benefits, these technologies share common challenges, including difficulties in image interpretation and steep learning curves. Looking forward, innovations in this field are poised to incorporate artificial intelligence, integrated multimodal imaging approaches, and augmented and virtual reality technologies. This rapidly evolving landscape represents fertile ground for future research and technological development, aiming to further elevate surgical precision, safety, and, most critically, patient outcomes in the management of brain tumors.

Original languageEnglish
Article number4890
Issue number19
StatePublished - Oct 2023
Externally publishedYes


  • advanced visualization techniques
  • brain tumor surgery
  • intraoperative imaging


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