Intranasal administration of nerve growth factor produces antidepressant-like effects in animals

Cui Ge Shi, Lu Ming Wang, Ying Wu, Peng Wang, Zhu Jun Gan, Kai Lin, Li Xin Jiang, Zhi Qing Xu, Ming Fan

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Many works showed that nerve growth factor (NGF) injected into the brain of animal model emerges potential antidepressant effects. However, this route of administration significantly restricts the application of NGF clinically. Here, we reported that intranasal NGF could provide an alternative to intraventricular injection. The behavioral analysis showed that intranasal administration of NGF reduced the immobility time in forced swimming test (FST) and tail suspension test (TST) in mice. Likewise, intranasal NGF increased the sucrose intake and the locomotor activity in rats after unpredictable chronic mild stress (UCMS). Furthermore, intranasal NGF increased the levels of monoamine neurotransmitters (norepinephrine, dopamine) in the frontal cortex and hippocampus and affected the number of 5-bromodeoxyuri-dine (BrdU), c-fos and caspase-3 positive neurons in dentate gyrus of hippocampus in rats after UCMS. In summary, intranasal NGF had significant antidepressant effects on animal models of depression and this route of administration may provide A promising way to deliver NGF to brain in A therapeutic perspective.

Original languageEnglish
Pages (from-to)1302-1314
Number of pages13
JournalNeurochemical Research
Issue number9
StatePublished - Sep 2010
Externally publishedYes


  • Depression Animal models
  • Intranasal delivery
  • NGF


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