Intrahepatic expression of hepatitis B virus antigens: Effect of hepatitis C virus infection

Maria Guido, Swan N. Thung, Giovanna Fattovich, Riccardo Cusinato, Gioacchino Leandro, Attilio Cecchetto, Simone Cesaro, Piero Panese, Massimo Rugge

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Coinfection with hepatitis B and C viruses (HBV, HCV) is not uncommon, but the expression of HBV antigens in the liver of patients with concomitant HCV infection has not been investigated. This study aimed to evaluate the effects of concomitant HCV infection on the intrahepatic expression of HBV antigens in chronic hepatitis. HBV surface and core antigens (HBsAg, HBcAg) were immunohistochemically evaluated and semiquantitatively scored in fiver biopsy specimens from patients with chronic hepatitis, comprising 17 cases with dual HBV/HCV infection and 25 with HBV infection alone. The prevalence of HBV Ag expression proved significantly lower in the group with dual infection. In the presence of active HBV replication (HBV DNA-positive serum) the prevalence of HBsAg and HBcAg immunoreaction was similar in the two groups, though a significantly lower percentage of cells expressed HBcAg in the group of coinfected patients. HBV Ag was not detected at all among HBV DNA-negative/HCV RNA-positive cases. In conclusion, these observations suggest that HCV might influence HBV antigen expression in the fiver and that either partial or complete suppression might occur.

Original languageEnglish
Pages (from-to)599-603
Number of pages5
JournalModern Pathology
Issue number6
StatePublished - Jun 1999
Externally publishedYes


  • Hepatitis B
  • Hepatitis C
  • Immunohistochemistry
  • Liver pathology
  • Viral coinfections
  • Viral hepatitis


Dive into the research topics of 'Intrahepatic expression of hepatitis B virus antigens: Effect of hepatitis C virus infection'. Together they form a unique fingerprint.

Cite this