Intracranial aneurysm wall displacement depicted by amplified Flow predicts growth

Aymeric Pionteck, Javid Abderezaei, Patrick Fillingham, Ya Chen Chuang, Yu Sakai, Puneet Belani, Brian Rigney, Reade De Leacy, Johanna T. Fifi, Aichi Chien, Geoffrey P. Colby, Reza Jahan, Gary Duckwiler, James Sayre, Samantha J. Holdsworth, Mahmud Mossa-Basha, Michael R. Levitt, J. Mocco, Mehmet Kurt, Kambiz Nael

Research output: Contribution to journalArticlepeer-review

Abstract

Background Abnormal intracranial aneurysm (IA) wall motion has been associated with IA growth and rupture. Recently, a new image processing algorithm called amplified Flow (aFlow) has been used to successfully track IA wall motion by combining the amplification of cine and four-dimensional (4D) Flow MRI. We sought to apply aFlow to assess wall motion as a potential marker of IA growth in a paired-wise analysis of patients with growing versus stable aneurysms. Methods In this retrospective case–control study, 10 patients with growing IAs and a matched cohort of 10 patients with stable IAs who had baseline 4D Flow MRI were included. The aFlow was used to amplify and extract IA wall displacements from 4D Flow MRI. The associations of aFlow parameters with commonly used risk factors and morphometric features were assessed using paired-wise univariate and multivariate analyses. Results aFlow quantitative results showed significantly (P=0.035) higher wall motion displacement depicted by mean±SD 90th% values of 2.34±0.72 in growing IAs versus 1.39±0.58 in stable IAs with an area under the curve of 0.85. There was also significantly (P<0.05) higher variability of wall deformation across IA geometry in growing versus stable IAs depicted by the dispersion variables including 121–150% larger standard deviation (σUN) and 128–161% wider interquartile range (IQRUN). Conclusions aFlow-derived quantitative assessment of IA wall motion showed greater wall motion and higher variability of wall deformation in growing versus stable IAs.

Original languageEnglish
JournalJournal of NeuroInterventional Surgery
DOIs
StateAccepted/In press - 2024

Keywords

  • Aneurysm
  • Magnetic Resonance Angiography
  • MRI
  • Vessel Wall

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