Intracortical eeg for the detection of vasospasm in patients with poor-grade subarachnoid hemorrhage

R. Morgan Stuart, Allen Waziri, David Weintraub, Michael J. Schmidt, Luis Fernandez, Raimund Helbok, Pedro Kurtz, Kiwon Lee, Neeraj Badjatia, Ron Emerson, Stephan A. Mayer, E. Sander Connolly, Lawrence J. Hirsch, Jan Claassen

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background: To study the feasibility of utilizing intracortical electroencephalography (ICE) including quantitative EEG (qEEG) analysis for the detection of vasospasm in five consecutive poor-grade SAH patients. Methods: Intracortical electroencephalography (ICE) was obtained via a single miniature parenchymal 8-contact depth electrode placed at the bedside. Quantitative EEG parameters, calculated on surface EEG and ICE, included alpha/delta ratio (ADR), mean amplitude, suppression percent, and total power. Percent changes between averaged values over 4-6 h of baseline EEG and EEG prior to angiography were calculated. The entire continuous qEEG recording for each patient was then reviewed to determine optimal automated alarm criteria. Results: ICE ADR was the most accurate for predicting angiographic vasospasm (5/5). ICE ADR decreased between baseline and follow-up by 42% (from 0.56 ± 0.07 to 0.32 ± 0.03) for those with vasospasm (N = 3) compared to 17% (0.62 ± 0.06 to 0.51 ± 0.03) for those without (N = 2). A sustained decrease in the ICE ADR from baseline (>25% for ≥4 h) occurred in all three patients with angiographically confirmed vasospasm and not in the two without; this decline occurred 1-3 days prior to angiographic confirmation. Conclusions: Intracortical EEG is promising for detecting ischemia from vasospasm in poor-grade SAH patients, may be superior to scalp EEG, and allow automated detection, particularly using the ADR. Larger studies are needed to better define the effectiveness of this approach.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalNeurocritical Care
Volume13
Issue number3
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Contiuous EEG
  • Delayed cerebral ischemia
  • Depth electrode
  • Intracortical electrode
  • Intracranial EEG
  • Multimodality monitoring
  • Quantitative EEG
  • Subarachnoid hemorrhage
  • Vasospasm
  • cEEG

Fingerprint

Dive into the research topics of 'Intracortical eeg for the detection of vasospasm in patients with poor-grade subarachnoid hemorrhage'. Together they form a unique fingerprint.

Cite this