Intracerebral Hemorrhage: A Common and Devastating Disease in Need of Better Treatment

Dave Fiorella, Scott L. Zuckerman, Imad S. Khan, Nishant K. Ganesh, J. Mocco

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


Objective To review the poor natural history of intracerebral hemorrhage (ICH), current treatment options for ICH, discuss ongoing trials evaluating minimally invasive techniques for clot evacuation, and offer future directions of investigation for the management of this devastating disease. Methods A selective review of recent trials regarding treatment of ICH was performed. Results Completed trials of medical and surgical management are reviewed. The supportive research for clot evacuation to limit secondary injury is surveyed. We also provide a comprehensive discussion of current data evaluating minimally invasive techniques to achieve clot removal, including Minimally Invasive Surgery plus tPA for ICH Evacuation (MISTIE), Clot Lysis: Evaluating Accelerated Resolution (CLEAR), and endoscopic evacuation. Conclusion We encourage the neurosurgical community to pursue improved therapies for ICH. Practice New minimally invasive treatments for ICH are being developed. Implications Treatment of ICH is an important area of research and should continue to be aggressively pursued because of the significant societal burden and poor outcomes associated with ICH.

Original languageEnglish
Pages (from-to)1136-1141
Number of pages6
JournalWorld Neurosurgery
Issue number4
StatePublished - Oct 2015
Externally publishedYes


  • Clot evacuation
  • Hemicraniectomy
  • Intracerebral hemorrhage
  • Thrombolysis


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