Intracerebral des-tyrosine-γ-endorphin inhibits methylphenidate induced locomotor activity

K. L. Davis; A. Samuel; A. A. Mathé; R. C. Mohs

doi:10.1016/0024-3205(81)90509-9

Intracerebral des-tyrosine-γ-endorphin inhibits methylphenidate induced locomotor activity

K. L. Davis
, A. Samuel
, A. A. Mathé
, R. C. Mohs

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Des-tyrosine-γ-endorphin (DTγE) administered directly into the nucleus accumbens inhibited the locomotor activity that follows the intraaccumbens injection of methylphenidate. In contrast, when DTγE was injected into the nucleus accumbens it had no effect on the locomotor behavior elicited by the direct injection of dopamine into the nucleus accumbens. These results suggest an interaction of DTγE with presynaptic rather than postsynaptic dopaminergic systems.

Original language	English
Pages (from-to)	2421-2424
Number of pages	4
Journal	Life Sciences
Volume	28
Issue number	21
DOIs	https://doi.org/10.1016/0024-3205(81)90509-9
State	Published - 21 May 1981
Externally published	Yes

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title = "Intracerebral des-tyrosine-γ-endorphin inhibits methylphenidate induced locomotor activity",

abstract = "Des-tyrosine-γ-endorphin (DTγE) administered directly into the nucleus accumbens inhibited the locomotor activity that follows the intraaccumbens injection of methylphenidate. In contrast, when DTγE was injected into the nucleus accumbens it had no effect on the locomotor behavior elicited by the direct injection of dopamine into the nucleus accumbens. These results suggest an interaction of DTγE with presynaptic rather than postsynaptic dopaminergic systems.",

author = "Davis, \{K. L.\} and A. Samuel and Math{\'e}, \{A. A.\} and Mohs, \{R. C.\}",

note = "Funding Information: This work was supported in part by the Veterans Administration Research Funds, a Schizophrenic Biological Research Center grant from the Veterans Administration and Henry and Lucy Moses Fund, Inc. New York.",

year = "1981",

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doi = "10.1016/0024-3205(81)90509-9",

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AU - Davis, K. L.

AU - Samuel, A.

AU - Mathé, A. A.

AU - Mohs, R. C.

N1 - Funding Information: This work was supported in part by the Veterans Administration Research Funds, a Schizophrenic Biological Research Center grant from the Veterans Administration and Henry and Lucy Moses Fund, Inc. New York.

PY - 1981/5/21

Y1 - 1981/5/21

N2 - Des-tyrosine-γ-endorphin (DTγE) administered directly into the nucleus accumbens inhibited the locomotor activity that follows the intraaccumbens injection of methylphenidate. In contrast, when DTγE was injected into the nucleus accumbens it had no effect on the locomotor behavior elicited by the direct injection of dopamine into the nucleus accumbens. These results suggest an interaction of DTγE with presynaptic rather than postsynaptic dopaminergic systems.

AB - Des-tyrosine-γ-endorphin (DTγE) administered directly into the nucleus accumbens inhibited the locomotor activity that follows the intraaccumbens injection of methylphenidate. In contrast, when DTγE was injected into the nucleus accumbens it had no effect on the locomotor behavior elicited by the direct injection of dopamine into the nucleus accumbens. These results suggest an interaction of DTγE with presynaptic rather than postsynaptic dopaminergic systems.

UR - https://www.scopus.com/pages/publications/0019870968

U2 - 10.1016/0024-3205(81)90509-9

DO - 10.1016/0024-3205(81)90509-9

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SP - 2421

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JO - Life Sciences

JF - Life Sciences

IS - 21

ER -

Intracerebral des-tyrosine-γ-endorphin inhibits methylphenidate induced locomotor activity

Abstract

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