Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma

Bryan D. Choi, Carter M. Suryadevara, Patrick C. Gedeon, James E. Herndon, Luis Sanchez-Perez, Darell D. Bigner, John H. Sampson

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors.

Original languageEnglish
Pages (from-to)189-190
Number of pages2
JournalJournal of Clinical Neuroscience
Volume21
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Central nervous system neoplasms
  • Epidermal growth factor receptor
  • Glioblastoma
  • Immunotherapy
  • T-lymphocytes

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