@article{227148c871974458ae85721e9a1074b6,
title = "Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma",
abstract = "Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors.",
keywords = "Central nervous system neoplasms, Epidermal growth factor receptor, Glioblastoma, Immunotherapy, T-lymphocytes",
author = "Choi, {Bryan D.} and Suryadevara, {Carter M.} and Gedeon, {Patrick C.} and Herndon, {James E.} and Luis Sanchez-Perez and Bigner, {Darell D.} and Sampson, {John H.}",
note = "Funding Information: This work was supported by grants from the National Institutes of Health: SRC on Primary Tumors of the Central Nervous System P50 NS020023-28 and 3R01-CA-135272-02S1 supplement for Brain Tumor Stem Cell R01. Additional support was provided by 5P50-NS020023-29, 5R01-CA135272-02S1, 5R01-CA134844-03, 5UL1-RR024128-05, 5R21-NS067980-02, and 5R21-NS068057-02. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",
year = "2014",
month = jan,
doi = "10.1016/j.jocn.2013.03.012",
language = "English",
volume = "21",
pages = "189--190",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",
number = "1",
}