Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles

Jun Zhao; Graham C.R. Ellis-Davies

doi:10.1039/d0cc03956j

Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles

Jun Zhao, Graham C.R. Ellis-Davies

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Photoswitchable drugs are small-molecule optical probes that undergo chromatically selective control of drug efficacy using, most often, UV-visible light. Here we report that luminescence produced by near-infrared stimulation of NaYF4:TmYb nanoparticles can be used for "remote control"of an azobenzene-based photochromic ion channel blocker of neurons in living brain slices.

Original language	English
Pages (from-to)	9445-9448
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	66
DOIs	https://doi.org/10.1039/d0cc03956j
State	Published - 25 Aug 2020

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title = "Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles",

abstract = "Photoswitchable drugs are small-molecule optical probes that undergo chromatically selective control of drug efficacy using, most often, UV-visible light. Here we report that luminescence produced by near-infrared stimulation of NaYF4:TmYb nanoparticles can be used for {"}remote control{"}of an azobenzene-based photochromic ion channel blocker of neurons in living brain slices.",

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AU - Zhao, Jun

AU - Ellis-Davies, Graham C.R.

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PY - 2020/8/25

Y1 - 2020/8/25

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AB - Photoswitchable drugs are small-molecule optical probes that undergo chromatically selective control of drug efficacy using, most often, UV-visible light. Here we report that luminescence produced by near-infrared stimulation of NaYF4:TmYb nanoparticles can be used for "remote control"of an azobenzene-based photochromic ion channel blocker of neurons in living brain slices.

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DO - 10.1039/d0cc03956j

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JO - Chemical Communications

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Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles

Abstract

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