Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

James J. Young; Joshua S. Friedman; Thomas J. Oxley; Christina Palmese; Fedor Panov; Saadi Ghatan; Johanna T. Fifi; Lara V. Marcuse

doi:10.1016/j.ebcr.2018.04.003

Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

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Abstract

The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Epilepsy and Behavior Case Reports
Volume	10
DOIs	https://doi.org/10.1016/j.ebcr.2018.04.003
State	Published - 1 Jan 2018

Keywords

Epilepsy surgery
Intracarotid amobarbital procedure
Phase amplitude coupling
Stereo-EEG
Synchrony
Wada

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10.1016/j.ebcr.2018.04.003

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title = "Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection",

abstract = "The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4{\textendash}30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.",

keywords = "Epilepsy surgery, Intracarotid amobarbital procedure, Phase amplitude coupling, Stereo-EEG, Synchrony, Wada",

author = "Young, \{James J.\} and Friedman, \{Joshua S.\} and Oxley, \{Thomas J.\} and Christina Palmese and Fedor Panov and Saadi Ghatan and Fifi, \{Johanna T.\} and Marcuse, \{Lara V.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = jan,

day = "1",

doi = "10.1016/j.ebcr.2018.04.003",

language = "English",

volume = "10",

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journal = "Epilepsy and Behavior Case Reports",

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TY - JOUR

T1 - Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

AU - Young, James J.

AU - Friedman, Joshua S.

AU - Oxley, Thomas J.

AU - Palmese, Christina

AU - Panov, Fedor

AU - Ghatan, Saadi

AU - Fifi, Johanna T.

AU - Marcuse, Lara V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.

AB - The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.

KW - Epilepsy surgery

KW - Intracarotid amobarbital procedure

KW - Phase amplitude coupling

KW - Stereo-EEG

KW - Synchrony

KW - Wada

UR - https://www.scopus.com/pages/publications/85047099660

U2 - 10.1016/j.ebcr.2018.04.003

DO - 10.1016/j.ebcr.2018.04.003

M3 - Article

AN - SCOPUS:85047099660

SN - 2213-3232

VL - 10

SP - 25

EP - 28

JO - Epilepsy and Behavior Case Reports

JF - Epilepsy and Behavior Case Reports

ER -

Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

Abstract

Keywords

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