Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

James J. Young; Joshua S. Friedman; Thomas J. Oxley; Christina Palmese; Fedor Panov; Saadi Ghatan; Johanna T. Fifi; Lara V. Marcuse

doi:10.1016/j.ebcr.2018.04.003

Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

James J. Young, Joshua S. Friedman, Thomas J. Oxley, Christina Palmese, Fedor Panov, Saadi Ghatan, Johanna T. Fifi, Lara V. Marcuse

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Epilepsy and Behavior Case Reports
Volume	10
DOIs	https://doi.org/10.1016/j.ebcr.2018.04.003
State	Published - 1 Jan 2018

Keywords

Epilepsy surgery
Intracarotid amobarbital procedure
Phase amplitude coupling
Stereo-EEG
Synchrony
Wada

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10.1016/j.ebcr.2018.04.003

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title = "Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection",

abstract = "The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.",

keywords = "Epilepsy surgery, Intracarotid amobarbital procedure, Phase amplitude coupling, Stereo-EEG, Synchrony, Wada",

author = "Young, {James J.} and Friedman, {Joshua S.} and Oxley, {Thomas J.} and Christina Palmese and Fedor Panov and Saadi Ghatan and Fifi, {Johanna T.} and Marcuse, {Lara V.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

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doi = "10.1016/j.ebcr.2018.04.003",

language = "English",

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T1 - Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

AU - Young, James J.

AU - Friedman, Joshua S.

AU - Oxley, Thomas J.

AU - Palmese, Christina

AU - Panov, Fedor

AU - Ghatan, Saadi

AU - Fifi, Johanna T.

AU - Marcuse, Lara V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.

AB - The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.

KW - Epilepsy surgery

KW - Intracarotid amobarbital procedure

KW - Phase amplitude coupling

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KW - Synchrony

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Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

Abstract

Keywords

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