Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial

Daniel J. Goldstein, Helena L. Chang, Michael J. Mack, Pierre Voisine, James S. Gammie, Mary E. Marks, Alexander Iribarne, Yuliya Vengrenyuk, Samantha Raymond, Bradley S. Taylor, François Dagenais, Gorav Ailawadi, Michael W.A. Chu, J. Michael DiMaio, Jagat Narula, Ellen G. Moquete, Karen O'Sullivan, Judson B. Williams, Juan A. Crestanello, Vincent ScavoJohn D. Puskas, Michael A. Acker, Marc Gillinov, Annetine C. Gelijns, Patrick T. O'Gara, Alan J. Moskowitz, John H. Alexander, Emilia Bagiella

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Diffuse intimal hyperplasia and graft irregularity adversely affect the long-term patency of saphenous vein grafts (SVGs) and clinical outcomes of patients undergoing coronary artery bypass grafting (CABG). The VEST trial evaluated the efficacy of external graft support in limiting the development of intimal hyperplasia (IH) at 1 year postsurgery. In the present secondary analysis, we explored the associations between graft disease and IH and clinical events. We also examined risk factors for early graft occlusion. Methods: VEST is a within-patient randomized, multicenter trial that enrolled 224 patients with multivessel coronary disease undergoing CABG surgery, of whom 203 were evaluated by 1 year postsurgery. Intimal hyperplasia, lumen uniformity, graft stenosis, and graft perfusion were measured by intravascular ultrasound and angiography. Major cardiac and cerebrovascular events (MACCE; including death, myocardial infarction, stroke, and revascularization) were recorded over a median follow-up of 3 years. Results: Worse lumen uniformity, greater stenosis, and worse graft perfusion were associated with higher IH values and an increased incidence of clinical events. Consistent with previous findings, we identified endoscopic vein harvesting, female sex, and transit time flow measurement of pulsatility index and flow as risk factors for SVG occlusion during the first year postsurgery. Conclusions: In this secondary analysis of the VEST trial, we observed an association between intimal hyperplasia area and clinical measures of SVG disease at 1 year postsurgery. More severe SVG disease and larger areas of IH were associated with a higher incidence of 3-year MACCE. Ongoing follow-up to 5 years will further elucidate the impact of SVG disease on long-term clinical outcomes of CABG.

Original languageEnglish
JournalJournal of Thoracic and Cardiovascular Surgery
StateAccepted/In press - 2022


  • CABG
  • intimal hyperplasia
  • saphenous vein graft disease


Dive into the research topics of 'Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial'. Together they form a unique fingerprint.

Cite this