Interventions for Posttraumatic Brain Injury Fatigue: An Updated Review

Melissa Shuman-Paretsky, Shinakee Gumber, Kristen Dams-O’Connor

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose of Review: To provide an updated review of empirical evidence in support of interventions for posttraumatic fatigue. Recent Findings: A total of 360 articles were published between January 22, 2014 and September 23, 2016 with nine meeting inclusion criteria. Articles included in this review provided further support for behavioral, pharmacological, and physical activity interventions for fatigue. Behavioral interventions remain popular, but studies directly targeting fatigue have not yet been undertaken. Pharmacological agents, particularly those using dopaminergic agents, showed potential but had mixed results. Interventions incorporating physical activity were promising but require more rigorous investigation. Summary: Despite promising results, there remains a need to replicate and further refine treatments using rigorous research designs and larger samples. Future studies should continue to more clearly define fatigue and use consistent subjective and objective endpoints that better capture this construct. Including imaging techniques would establish the effectiveness and mechanisms of interventions.

Original languageEnglish
Pages (from-to)12-21
Number of pages10
JournalCurrent Physical Medicine and Rehabilitation Reports
Issue number1
StatePublished - 1 Mar 2017


  • Fatigue
  • Intervention
  • PTBIF treatment
  • Posttraumatic brain injury fatigue: PTBIF
  • Review
  • Traumatic brain injury


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