Interrelationships between μ opioid and melanocortin receptors in mediating food intake in rats

Henya C. Grossman, Maria M. Hadjimarkou, Robert M. Silva, Silvia Q. Giraudo, Richard J. Bodnar

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The present study examined the interrelationships between feeding responses produced by μ opioid receptor agonists and melanocortin-3 or 4 (MC-3/4) receptor antagonists. Feeding induced by the μ-sensitive opioid peptide, β-endorphin (βEND, 10 μg, icv) was significantly and dose-dependently reduced by pretreatment with the MC-3/4 receptor agonist, melanotan-II (MTII: 0.01-10 nmol, icv). Moreover, the selective μ opioid antagonist, β-funaltrexamine (βFNA: 2-20 μg, icv), significantly and dose-dependently reduced feeding and weight gain elicited by the potent MC-3/4 receptor antagonist, SHU-9119 (0.5 nmol, icv), especially at those intake periods (24-48 h) when SHU-9119 produced maximal ingestive effects. These data extend previous findings demonstrating interactions between opioid and melanocortin receptors in the mediation of food intake.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalBrain Research
Issue number1-2
StatePublished - 21 Nov 2003
Externally publishedYes


  • Body weight
  • Food intake
  • MTII
  • SHU-9119
  • β- Funaltrexamine
  • β-Endorphin


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