TY - JOUR
T1 - Interrater reliability of the new criteria for behavioral variant frontotemporal dementia
AU - La Marre, Amanda K.
AU - Rascovsky, Katya
AU - Bostrom, Alan
AU - Toofanian, Parnian
AU - Wilkins, Sarah
AU - Sha, Sharon J.
AU - Perry, David C.
AU - Miller, Zachary A.
AU - Naasan, Georges
AU - Laforce, Robert
AU - Hagen, Jayne
AU - Takada, Leonel T.
AU - Tartaglia, Maria Carmela
AU - Kang, Gail
AU - Galasko, Douglas
AU - Salmon, David P.
AU - Farias, Sarah Tomaszewski
AU - Kaur, Berneet
AU - Olichney, John M.
AU - Park, Lovingly Quitania
AU - Mendez, Mario F.
AU - Tsai, Po Heng
AU - Teng, Edmond
AU - Dickerson, Bradford Clark
AU - Domoto-Reilly, Kimiko
AU - McGinnis, Scott
AU - Miller, Bruce L.
AU - Kramer, Joel H.
PY - 2013/5/21
Y1 - 2013/5/21
N2 - Objective: To evaluate the interrater reliability of the new International Behavioural Variant FTD Criteria Consortium (FTDC) criteria for behavioral variant frontotemporal dementia (bvFTD). Methods: Twenty standardized clinical case modules were developed for patients with a range of neurodegenerative diagnoses, including bvFTD, primary progressive aphasia (nonfluent, semantic, and logopenic variant), Alzheimer disease, and Lewy body dementia. Eighteen blinded raters reviewed the modules and 1) rated the presence or absence of core diagnostic features for the FTDC criteria, and 2) provided an overall diagnostic rating. Interrater reliability was determined by k statistics for multiple raters with categorical ratings. Results: The mean k value for diagnostic agreement was 0.81 for possible bvFTD and 0.82 for probable bvFTD ("almost perfect agreement"). Interrater reliability for 4 of the 6 core features had "substantial" agreement (behavioral disinhibition, perseverative/compulsive, sympathy/empathy, hyperorality; k = 0.61-0.80), whereas 2 had "moderate" agreement (apathy/inertia, neuropsychological; k = 0.41-0.6). Clinician years of experience did not significantly influence rater accuracy. Conclusions: The FTDC criteria show promise for improving the diagnostic accuracy and reliability of clinicians and researchers. As disease-altering therapies are developed, accurate differential diagnosis between bvFTD and other neurodegenerative diseases will become increasingly important.
AB - Objective: To evaluate the interrater reliability of the new International Behavioural Variant FTD Criteria Consortium (FTDC) criteria for behavioral variant frontotemporal dementia (bvFTD). Methods: Twenty standardized clinical case modules were developed for patients with a range of neurodegenerative diagnoses, including bvFTD, primary progressive aphasia (nonfluent, semantic, and logopenic variant), Alzheimer disease, and Lewy body dementia. Eighteen blinded raters reviewed the modules and 1) rated the presence or absence of core diagnostic features for the FTDC criteria, and 2) provided an overall diagnostic rating. Interrater reliability was determined by k statistics for multiple raters with categorical ratings. Results: The mean k value for diagnostic agreement was 0.81 for possible bvFTD and 0.82 for probable bvFTD ("almost perfect agreement"). Interrater reliability for 4 of the 6 core features had "substantial" agreement (behavioral disinhibition, perseverative/compulsive, sympathy/empathy, hyperorality; k = 0.61-0.80), whereas 2 had "moderate" agreement (apathy/inertia, neuropsychological; k = 0.41-0.6). Clinician years of experience did not significantly influence rater accuracy. Conclusions: The FTDC criteria show promise for improving the diagnostic accuracy and reliability of clinicians and researchers. As disease-altering therapies are developed, accurate differential diagnosis between bvFTD and other neurodegenerative diseases will become increasingly important.
UR - http://www.scopus.com/inward/record.url?scp=84879104941&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e318293e368
DO - 10.1212/WNL.0b013e318293e368
M3 - Article
C2 - 23635967
AN - SCOPUS:84879104941
SN - 0028-3878
VL - 80
SP - 1973
EP - 1977
JO - Neurology
JF - Neurology
IS - 21
ER -