Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis

Erming Tian; Magne Boørset; Bart Barlogie; John D. Shaughnessy

doi:10.1109/BMEI.2009.5305102

Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis

Erming Tian
, Magne Boørset
, Bart Barlogie
, John D. Shaughnessy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Due to the heterogeneity of the myeloma genomes, it is unlikely to remedy the disease with a standard therapeutic protocol. In principle, all therapies are considered palliative. To achieve the best clinical outcomes, the therapeutic protocols were implemented with high-dose chemotherapies followed by autologous hematopoietic stem cell transplantation as the standard treatments for newly diagnosed myeloma cases. In parallel with the clinical protocols, bone marrow specimens were collected at the diagnosis stage of more than 500 patients. The assessment of the prognostic and predictive impact of cytogenetic anomalies in the tumor cells was carried out using fluorescent in situ hybridization (FISH) procedure to probe chromosome 1q21, 1p13, 13q14, and 13q34 regions. The cytogenetic aberrations in myeloma cells are corroborated with clinical observation for the prognostic significance. The current study revealed that the amplification of 1q21 and deletion of 1p13 chromosome regions are the significant risk factors when considering overall survival and event-free survival of the patients.

Original language	English
Title of host publication	Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
Publisher	IEEE Computer Society
ISBN (Print)	9781424441341
DOIs	https://doi.org/10.1109/BMEI.2009.5305102
State	Published - 2009
Externally published	Yes
Event	2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Held in conjunction with the 2nd International Congress on Image and Signal Processing, CISP 2009 - Tianjin, China Duration: 17 Oct 2009 → 19 Oct 2009

Publication series

Name	Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

Conference

Conference	2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Held in conjunction with the 2nd International Congress on Image and Signal Processing, CISP 2009
Country/Territory	China
City	Tianjin
Period	17/10/09 → 19/10/09

Keywords

Cancer survival
Cytogenetics
FISH
Multiple myeloma
Risk factor

Access to Document

10.1109/BMEI.2009.5305102

Cite this

Tian, E., Boørset, M., Barlogie, B., & Shaughnessy, J. D. (2009). Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis. In Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009 Article 5305102 (Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009). IEEE Computer Society. https://doi.org/10.1109/BMEI.2009.5305102

Tian, Erming ; Boørset, Magne ; Barlogie, Bart et al. / Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis. Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009. IEEE Computer Society, 2009. (Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009).

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title = "Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis",

abstract = "Due to the heterogeneity of the myeloma genomes, it is unlikely to remedy the disease with a standard therapeutic protocol. In principle, all therapies are considered palliative. To achieve the best clinical outcomes, the therapeutic protocols were implemented with high-dose chemotherapies followed by autologous hematopoietic stem cell transplantation as the standard treatments for newly diagnosed myeloma cases. In parallel with the clinical protocols, bone marrow specimens were collected at the diagnosis stage of more than 500 patients. The assessment of the prognostic and predictive impact of cytogenetic anomalies in the tumor cells was carried out using fluorescent in situ hybridization (FISH) procedure to probe chromosome 1q21, 1p13, 13q14, and 13q34 regions. The cytogenetic aberrations in myeloma cells are corroborated with clinical observation for the prognostic significance. The current study revealed that the amplification of 1q21 and deletion of 1p13 chromosome regions are the significant risk factors when considering overall survival and event-free survival of the patients.",

keywords = "Cancer survival, Cytogenetics, FISH, Multiple myeloma, Risk factor",

author = "Erming Tian and Magne Bo{\o}rset and Bart Barlogie and Shaughnessy, \{John D.\}",

year = "2009",

doi = "10.1109/BMEI.2009.5305102",

language = "English",

isbn = "9781424441341",

series = "Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009",

publisher = "IEEE Computer Society",

booktitle = "Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009",

address = "United States",

note = "2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Held in conjunction with the 2nd International Congress on Image and Signal Processing, CISP 2009 ; Conference date: 17-10-2009 Through 19-10-2009",

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Tian, E, Boørset, M, Barlogie, B & Shaughnessy, JD 2009, Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis. in Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009., 5305102, Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, IEEE Computer Society, 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Held in conjunction with the 2nd International Congress on Image and Signal Processing, CISP 2009, Tianjin, China, 17/10/09. https://doi.org/10.1109/BMEI.2009.5305102

Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis. / Tian, Erming; Boørset, Magne; Barlogie, Bart et al.
Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009. IEEE Computer Society, 2009. 5305102 (Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis

AU - Tian, Erming

AU - Boørset, Magne

AU - Barlogie, Bart

AU - Shaughnessy, John D.

PY - 2009

Y1 - 2009

N2 - Due to the heterogeneity of the myeloma genomes, it is unlikely to remedy the disease with a standard therapeutic protocol. In principle, all therapies are considered palliative. To achieve the best clinical outcomes, the therapeutic protocols were implemented with high-dose chemotherapies followed by autologous hematopoietic stem cell transplantation as the standard treatments for newly diagnosed myeloma cases. In parallel with the clinical protocols, bone marrow specimens were collected at the diagnosis stage of more than 500 patients. The assessment of the prognostic and predictive impact of cytogenetic anomalies in the tumor cells was carried out using fluorescent in situ hybridization (FISH) procedure to probe chromosome 1q21, 1p13, 13q14, and 13q34 regions. The cytogenetic aberrations in myeloma cells are corroborated with clinical observation for the prognostic significance. The current study revealed that the amplification of 1q21 and deletion of 1p13 chromosome regions are the significant risk factors when considering overall survival and event-free survival of the patients.

AB - Due to the heterogeneity of the myeloma genomes, it is unlikely to remedy the disease with a standard therapeutic protocol. In principle, all therapies are considered palliative. To achieve the best clinical outcomes, the therapeutic protocols were implemented with high-dose chemotherapies followed by autologous hematopoietic stem cell transplantation as the standard treatments for newly diagnosed myeloma cases. In parallel with the clinical protocols, bone marrow specimens were collected at the diagnosis stage of more than 500 patients. The assessment of the prognostic and predictive impact of cytogenetic anomalies in the tumor cells was carried out using fluorescent in situ hybridization (FISH) procedure to probe chromosome 1q21, 1p13, 13q14, and 13q34 regions. The cytogenetic aberrations in myeloma cells are corroborated with clinical observation for the prognostic significance. The current study revealed that the amplification of 1q21 and deletion of 1p13 chromosome regions are the significant risk factors when considering overall survival and event-free survival of the patients.

KW - Cancer survival

KW - Cytogenetics

KW - FISH

KW - Multiple myeloma

KW - Risk factor

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T3 - Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

BT - Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

PB - IEEE Computer Society

T2 - 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Held in conjunction with the 2nd International Congress on Image and Signal Processing, CISP 2009

Y2 - 17 October 2009 through 19 October 2009

ER -

Tian E, Boørset M, Barlogie B, Shaughnessy JD. Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis. In Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009. IEEE Computer Society. 2009. 5305102. (Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009). doi: 10.1109/BMEI.2009.5305102

Interphase FISH of chromosome 1 and 13 in newly diagnosed myeloma and the disease prognosis

Abstract

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Keywords

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