International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023

Thomas P. Burris, Ian Mitchelle S. de Vera, Isabelle Cote, Colin A. Flaveny, Udayanga S. Wanninayake, Arindam Chatterjee, John K. Walker, Nickolas Steinauer, Jinsong Zhang, Laurel A. Coons, Kenneth S. Korach, Derek W. Cain, Anthony N. Hollenberg, Paul Webb, Douglas Forrest, Anton M. Jetten, Dean P. Edwards, Sandra L. Grimm, Sean Hartig, Carol A. LangeJennifer K. Richer, Carol A. Sartorius, Marc Tetel, Cyrielle Billon, Bahaa Elgendy, Lamees Hegazy, Kristine Griffett, Nahuel Peinetti, Kerry L. Burnstein, Travis S. Hughes, Sadichha Sitaula, Keitch R. Stayrook, Alexander Culver, Meghan H. Murray, Brian N. Finck, John A. Cidlowski

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The NR superfamily comprises 48 transcription factors in humans that control a plethora of gene network programs involved in awide range of physiologic processes. This review will summarize and discuss recent progress in NR biology and drug development derived from integrating various approaches, including biophysical techniques, structural studies, and translational investigation. We also highlight how defective NR signaling results in various diseases and disorders and how NRs can be targeted for therapeutic intervention via modulation via binding to synthetic lipophilic ligands. Furthermore, we also review recent studies that improved our understanding ofNRstructure and signaling. Significance Statement——Nuclear receptors (NRs) are ligand-regulated transcription factors that are critical regulators of myriad physiological processes. NRs serve as receptors for an array of drugs, and in this review, we provide an update on recent research into the roles of these drug targets.

Original languageEnglish
Pages (from-to)1233-1318
Number of pages86
JournalPharmacological Reviews
Issue number6
StatePublished - 1 Nov 2023
Externally publishedYes


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