TY - JOUR
T1 - International collaborative study on genetic susceptibility to environmental carcinogens (GSEC)
T2 - An update
AU - Gaspari, L.
AU - Marinelli, D.
AU - Taioli, E.
N1 - Funding Information:
Acknowledgements. The study was supported by the European Commission Fund n. 96/CAN/ 33919. We thank Samantha Garbers, Giovanna Bognandi and Cinzia Petrazzoli for technical assistance.
Funding Information:
A pooled analysis of studies involving susceptibility gene polymorphisms was started in 1996, as a collaborative project funded by the European Commission. The project has several aims: 1) to study the gene frequency in the healthy population, according to ethnicity and geographical distribution. 2) to study the association between each gene polymorphism and cancer 3) to assess gene-environment interaction by pooling a larger enough group of people. 4) to study the effect of multiple gene polymorphisms on cancer risk. A first description of the study has been published elsewhere (Taioli, 1999).
PY - 2001
Y1 - 2001
N2 - We have created a database of published and unpublished studies on genetic susceptibility to environmental carcinogens, by bringing together many single studies that are too small to give definitive answers on the role of metabolic genes in cancer susceptibility. Possible participants were identified through a literature search of case control studies published up to June 1999 on metabolic gene polymorphisms and cancer, and invited to send their data sets without personal identifiers. Individual data from a total of over 30,000 subjects (52% cancer cases, 48% controls) have been collected. The most common type of cancer is lung, followed by bladder, head and neck, and breast. Demographic data, such as age, sex, and race were obtained for almost all the subjects. Main exposures, such as smoking, alcohol, occupational exposure were also included in a portion of the data set. The simultaneous presence of two gene polymorphisms has been assessed in 3535 controls and 3445 cases. An Advisory Committee has evaluated and approved 8 proposals to analyze the available data. This project allows the study of the main effects of genes, gene-exposure effects, ethnic and geographic differences in allele frequencies, gene-environment and gene-gene interaction as possible risk factors for cancer.
AB - We have created a database of published and unpublished studies on genetic susceptibility to environmental carcinogens, by bringing together many single studies that are too small to give definitive answers on the role of metabolic genes in cancer susceptibility. Possible participants were identified through a literature search of case control studies published up to June 1999 on metabolic gene polymorphisms and cancer, and invited to send their data sets without personal identifiers. Individual data from a total of over 30,000 subjects (52% cancer cases, 48% controls) have been collected. The most common type of cancer is lung, followed by bladder, head and neck, and breast. Demographic data, such as age, sex, and race were obtained for almost all the subjects. Main exposures, such as smoking, alcohol, occupational exposure were also included in a portion of the data set. The simultaneous presence of two gene polymorphisms has been assessed in 3535 controls and 3445 cases. An Advisory Committee has evaluated and approved 8 proposals to analyze the available data. This project allows the study of the main effects of genes, gene-exposure effects, ethnic and geographic differences in allele frequencies, gene-environment and gene-gene interaction as possible risk factors for cancer.
KW - Cancer
KW - Metabolic genes
KW - Molecular epidemiology
KW - Pooled analysis
UR - https://www.scopus.com/pages/publications/0034761843
U2 - 10.1078/1438-4639-00070
DO - 10.1078/1438-4639-00070
M3 - Article
C2 - 11725343
AN - SCOPUS:0034761843
SN - 1438-4639
VL - 204
SP - 39
EP - 42
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
IS - 1
ER -