Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease

Pierre Desreumaux, Anne Janin, Jean Frédéric Colombel, Lionel Prin, Joël Desreumaux, Dominique Emilie, Gérard Torpier, André Capron, Monique Capron

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196 Scopus citations

Abstract

Interleukin 5 (IL-5), the major factor involved ineosinophil differentiation, is produced by T cells or mast cells. In the present study, we found that eosinophils infiltrating the mucosa of four patients with active coeliac disease also express the IL-5 mRNA. No positive signal was obtained in normal duodenum tissues and in the cell infiltratefrom patients submitted to gluten restriction. The identification of labeled mucosal cells as eosinophils relied on their typical morphology. Moreover, highly purified blood eosinophils from three out of four patients with eosinophiliawere also strongly labeled with the IL-5 antisense but not with the corresponding sense probe. Together, these resultssuggest that eosinophils have the capacity to synthesize IL-5, which could contribute to paracrine interactions with Tand B cells and, in autocrine fashion, locally partidpate, through binding to the IL-5 receptor, to eosinophil differentiation and activation. These data might have implicationsnot only in the pathology of coeliac disease but also in other diseases associated with eosinophil infiltration.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalJournal of Experimental Medicine
Volume175
Issue number1
DOIs
StatePublished - 1 Jan 1992
Externally publishedYes

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