Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

Tiziana Musso; G. Luca Gusella; Alan Brooks; Dan L. Longo; Luigi Varesio

doi:10.1182/blood.v83.5.1408.1408

Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

Tiziana Musso, G. Luca Gusella, Alan Brooks, Dan L. Longo, Luigi Varesio

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128 Scopus citations

Abstract

Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-γ (IFNγ). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFNγ in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan.

Original language	English
Pages (from-to)	1408-1411
Number of pages	4
Journal	Blood
Volume	83
Issue number	5
DOIs	https://doi.org/10.1182/blood.v83.5.1408.1408
State	Published - 1 Mar 1994

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title = "Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes",

abstract = "Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-γ (IFNγ). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFNγ in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan.",

author = "Tiziana Musso and Gusella, {G. Luca} and Alan Brooks and Longo, {Dan L.} and Luigi Varesio",

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T1 - Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

AU - Musso, Tiziana

AU - Gusella, G. Luca

AU - Brooks, Alan

AU - Longo, Dan L.

AU - Varesio, Luigi

PY - 1994/3/1

Y1 - 1994/3/1

N2 - Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-γ (IFNγ). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFNγ in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan.

AB - Indoleamine 2,3-dioxygenase (IDO), a flavin-dependent enzyme that catalyzes the conversion of tryptophan to kynurenine, is induced in peripheral blood mononuclear cells by interferon-γ (IFNγ). Interleukin-4 (IL-4) is a cytokine that modulates the functional properties of monocytes/macrophages, and we investigated the effects of IL-4 on IDO. We showed that IL-4 inhibited the induction of IDO mRNA and IDO activity by IFNγ in human monocytes. The inhibitory effect was evident with as little as 2 U/mL of IL-4. These results provide the first evidence that a cytokine can provide a negative signal for IDO expression and that IL-4 can influence the catabolism of tryptophan.

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DO - 10.1182/blood.v83.5.1408.1408

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SN - 0006-4971

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JO - Blood

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Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes

Abstract

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