IL-33 is a potent activator of type 2 immune responses via the stimulation of ILC2s, but the downstream pathways triggered in these cells are poorly defined. Flamar and colleagues show that IL-33 controls tryptophan hydroxylase 1 expression in ILC2s, which is required for type 2 immunity against worm infections.
- group 2 innate lymphoid cells
- helminth infection
- inflammatory ILC2s
- tryptophan hydroxylase 1
- type 2 immunity