Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction

Saiju Pyarajan, Gabriel Matejovic, Joanne C. Pratt, Shairaz Baksh, Steven J. Burakoff

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Interleukin-3 (IL-3) regulates cell growth by affecting various processes such as cell death, survival, and proliferation. Cues from the external environment are sensed by surface receptors, and complex signaling mechanisms arise within the cells, leading to specific functional outcomes. In this study, we demonstrate that the cytokine IL-3 induces the activation of the Ca 2+-dependent phosphatase, calcineurin (Cn). Furthermore Cn dephosphorylates Gab2, resulting in c-fos activation and cell proliferation. We also report that there is a direct interaction between Cn and Gab2 upon IL-3 stimulation, and Akt can regulate this interaction.

Original languageEnglish
Pages (from-to)23505-23509
Number of pages5
JournalJournal of Biological Chemistry
Issue number35
StatePublished - 29 Aug 2008


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