Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

J. Cj Martin, G. Bériou, M. Heslan, C. Chauvin, L. Utriainen, A. Aumeunier, C. L. Scott, A. Mowat, V. Cerovic, S. A. Houston, M. Leboeuf, F. X. Hubert, C. Hémont, M. Merad, S. Milling, R. Josien

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124 Scopus citations

Abstract

Interleukin-22 (IL-22) is mainly produced at barrier surfaces by T cells and innate lymphoid cells and is crucial to maintain epithelial integrity. However, dysregulated IL-22 action leads to deleterious inflammation and is involved in diseases such as psoriasis, intestinal inflammation, and cancer. IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 receptor and may represent a crucial regulator of IL-22. We show both in rats and mice that, in the steady state, the main source of IL-22BP is constituted by a subset of conventional dendritic cells (DCs) in lymphoid and non-lymphoid tissues. In mouse intestine, IL-22BP was specifically expressed in lamina propria CD103 + CD11b + DC. In humans, IL-22BP was expressed in immature monocyte-derived DC and strongly induced by retinoic acid but dramatically reduced upon maturation. Our data suggest that a subset of immature DCs may actively participate in the regulation of IL-22 activity in the gut by producing high levels of IL-22BP.

Original languageEnglish
Pages (from-to)101-113
Number of pages13
JournalMucosal Immunology
Volume7
Issue number1
DOIs
StatePublished - Jan 2014

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