Interferon suppresses antigen- and mitogen-induced leukocyte migration inhibition

R. Szigeti; Maria G. Masucci; G. Masucci; Eva Klein; G. Klein; W. Berthold

doi:10.1038/288594a0

Interferon suppresses antigen- and mitogen-induced leukocyte migration inhibition

R. Szigeti, Maria G. Masucci, G. Masucci, Eva Klein, G. Klein, W. Berthold

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14 Scopus citations

Abstract

Although first recognized by its effect on virus-cell interactions, interferon (IFN)¹ has a variety of other effects². It can affect cell proliferation^3,4, modify the immune response at several levels⁵, enhance the cytotoxic action of lymphocytes^6-9, suppress antibody formation¹⁰ and inhibit the development of delayed-type hypersensitivity (DTH) reactions^11,12. Therefore we have now tested the effect of interferon on leukocyte migration inhibition (LMI), regarded as the counterpart in vitro of DTH in humans¹³. We have found that IFN suppresses both mitogen-and antigen-induced LMI, acting directly on the granulocytes but also affecting the lymphokine production of the lymphocytes.

Original language	English
Pages (from-to)	594-596
Number of pages	3
Journal	Nature
Volume	288
Issue number	5791
DOIs	https://doi.org/10.1038/288594a0
State	Published - 1980
Externally published	Yes

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title = "Interferon suppresses antigen- and mitogen-induced leukocyte migration inhibition",

abstract = "Although first recognized by its effect on virus-cell interactions, interferon (IFN)1 has a variety of other effects2. It can affect cell proliferation3,4, modify the immune response at several levels5, enhance the cytotoxic action of lymphocytes6-9, suppress antibody formation10 and inhibit the development of delayed-type hypersensitivity (DTH) reactions11,12. Therefore we have now tested the effect of interferon on leukocyte migration inhibition (LMI), regarded as the counterpart in vitro of DTH in humans13. We have found that IFN suppresses both mitogen-and antigen-induced LMI, acting directly on the granulocytes but also affecting the lymphokine production of the lymphocytes.",

author = "R. Szigeti and Masucci, {Maria G.} and G. Masucci and Eva Klein and G. Klein and W. Berthold",

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AU - Szigeti, R.

AU - Masucci, Maria G.

AU - Masucci, G.

AU - Klein, Eva

AU - Klein, G.

AU - Berthold, W.

PY - 1980

Y1 - 1980

N2 - Although first recognized by its effect on virus-cell interactions, interferon (IFN)1 has a variety of other effects2. It can affect cell proliferation3,4, modify the immune response at several levels5, enhance the cytotoxic action of lymphocytes6-9, suppress antibody formation10 and inhibit the development of delayed-type hypersensitivity (DTH) reactions11,12. Therefore we have now tested the effect of interferon on leukocyte migration inhibition (LMI), regarded as the counterpart in vitro of DTH in humans13. We have found that IFN suppresses both mitogen-and antigen-induced LMI, acting directly on the granulocytes but also affecting the lymphokine production of the lymphocytes.

AB - Although first recognized by its effect on virus-cell interactions, interferon (IFN)1 has a variety of other effects2. It can affect cell proliferation3,4, modify the immune response at several levels5, enhance the cytotoxic action of lymphocytes6-9, suppress antibody formation10 and inhibit the development of delayed-type hypersensitivity (DTH) reactions11,12. Therefore we have now tested the effect of interferon on leukocyte migration inhibition (LMI), regarded as the counterpart in vitro of DTH in humans13. We have found that IFN suppresses both mitogen-and antigen-induced LMI, acting directly on the granulocytes but also affecting the lymphokine production of the lymphocytes.

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VL - 288

SP - 594

EP - 596

JO - Nature

JF - Nature

IS - 5791

ER -

Interferon suppresses antigen- and mitogen-induced leukocyte migration inhibition

Abstract

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