Interferon lambda and hepatitis C virus core protein polymorphisms associated with liver cancer

João Paulo Moreira, Fernanda De Mello Malta, Márcio Augusto Diniz, Luciana Kikuchi, Aline Lopes Chagas, Livia De Souza Botelho Lima, Michele Soares Gomes-Gouvêa, Vanessa Fusco Duarte De Castro, Rubia Anita Ferraz Santana, Nairo Massakazu Sumita, Denise Cerqueira Paranagua Vezozzo, Flair José Carrilho, João Renato Rebello Pinho

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Hepatitis C virus (HCV) infection is often persistent and gradually advances from chronic hepatitis to liver cirrhosis and hepatocellular carcinoma (HCC). Worldwide, hepatocellular carcinoma is the fifth most common neoplasm. Method of study: the Interferon lambda (IFNL) polymorphisms genotypes (rs8099917, rs12979860 and rs12980275) and the presence of mutations in HCV core protein were analyzed in 59 patients with HCC, and also in 50 cirrhotic patients (without HCC). Results: the rs12980275-AG genotype was associated with HCC on age-adjusted analysis (OR 2.42, 95% CI 1.03-5.69, P=0.043). Core substitutions R70Q and L91M were mainly found in genotype 1b isolates. Furthermore, a borderline level of statistical significance association was found among the presence of amino acid Glutamine (Q) in the position 70 and IFNL3 genotype AG (P=0.054). Conclusions: the screening of these polymorphisms and functional studies would be useful in clinical practice for identifying groups at high risk of HCC development.

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalVirology
Volume493
DOIs
StatePublished - 1 Jun 2016
Externally publishedYes

Keywords

  • Chronic hepatitis
  • Hepatitis C virus
  • Immune responses
  • Infection
  • Mutation
  • Oncogenesis

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