Interferon: A perspective

R. M. Weisman, M. J. Droller

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Interferon clearly represents a family of glycoproteins with important and varied biological effects the most significant of which include the ability to initiate a nonspecific antiviral state, inhibit cell multiplication, and modulate the immune system. Although the mechanisms for each effect may be different and remain unresolved, interferon's important alterations of cell surfaces may represent the significant common denominator. Although numerous in vitro and in vivo animals studies have shown that interferon possesses potent antitumor and antiviral capabilities, human trials, although promising, are still too few and too early to be conclusive. An evaluation of interferon's true efficacy must await large-scale randomized studies with higher doses of much purer preparations. However, interferon may be a most important substance and certainly deserves much of its recent publicity, as well as further major investigation.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalInvestigative Urology
Volume18
Issue number3
StatePublished - 1980
Externally publishedYes

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