Interactions of NF-κB with chromatin: The art of being at the right place at the right time

Gioacchino Natoli, Simona Saccani, Daniela Bosisio, Ivan Marazzi

Research output: Contribution to journalReview articlepeer-review

223 Scopus citations

Abstract

Transcription factors of the NF-κB family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-κB activation is cytoplasmic and leads to the release of NF-κB proteins from IκB molecules, specific inhibitors that prevent their nuclear accumulation. However, it is becoming increasingly apparent that in addition to this required activation step, both recruitment of NF-κB to target genes and NF-κB-induced transcriptional events after recruitment are actively controlled. Regulated recruitment of NF-κB to chromatin generates kinetic complexity in NF-κB-dependent gene induction and 'wires' NF-κB-regulated gene activity to simultaneously activated pathways and transcription factors.

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalNature Immunology
Volume6
Issue number5
DOIs
StatePublished - 2005
Externally publishedYes

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