Interactions between microstructural and geometrical adaptation in human cortical bone

Ani Ural, Deepak Vashishth

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

With aging and in disease, the changes in bone microstructure and geometry influence the mechanical properties of cortical bone, however, the level of interaction between the two is not known. Here, we investigate the interaction between the changes in microstructural and geometrical properties of the aging male tibia in proximal and distal middiaphysis. The microstructural measurements include variables related to the size and density of osteons and intracortical porosity. The macroscopic geometrical properties include variables related to bone surfaces (periosteal and endosteal) and cross section (area, moment of inertia). Site-specific correlations were found between the microstructural and geometrical properties along the bone length and at different bone surfaces. In contrast to the proximal middiaphysis of male tibia, where no correlation existed, significant (p < 0.05) correlations were found in the distal middiaphysis of tibia. The changes in parameters partially related to bone formation in the cortex, including the osteonal area, showed positive correlations with an increase in the periosteal diameter. Similarly, parameters related to bone resorption and/or failed formation in the cortex, including porosity and pore size, showed significant correlations with cortical thinning. These findings support the concept that, with aging, anabolic and catabolic responses in the human tibia at microstructural and macrostructural levels are spatially related and site specific.

Original languageEnglish
Pages (from-to)1489-1498
Number of pages10
JournalJournal of Orthopaedic Research
Volume24
Issue number7
DOIs
StatePublished - Jul 2006
Externally publishedYes

Keywords

  • Bone adaptation
  • Bone size
  • Microstructure
  • Modeling
  • Remodeling

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