Interactions between dead cells and dendritic cells in the induction of antiviral CTL responses

Jean François Fonteneau, Marie Larsson, Nina Bhardwaj

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Dendritic cells - professional antigen-presenting cells - are key players for activating adaptive immune responses against viruses. Apoptosis or lytic cell death often accompanies viral infection. Dendritic cells can acquire infected dead or dying cells as exogenous sources of antigens for presentation on MHC class I and II molecules to initiate T cell responses. This pathway of activating T cells may be critical for the development of effective antiviral immunity in vivo.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalCurrent Opinion in Immunology
Volume14
Issue number4
DOIs
StatePublished - 1 Aug 2002
Externally publishedYes

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