Interaction of Mycoplasma arthritidis Superantigen with Human T Cells

David N. Posnett, Andrew S. Hodtsev, Shara Kabak, Steven M. Friedman, Barry C. Cole, Nina Bhardwaj

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

To define the interaction site of T cell antigen receptors (TCRs) with the superantigen of Mycoplasma arthritidis (MAM), we characterized the TCRs of human MAM-reactive T cell lines and T cell clones. Most MAM-reactive T cells express the Vβ17 gene segment; however, other Vβ may also be used and not all Vβ17+TCRs are MAM-reactive. Alignment of MAM-reactive and MAM-nonreactive Vβ sequences suggests that MAM does not interact with a single site encoded by a Vβ segment but that several sites may be involved or that other TCR elements contribute to formation of the MAM recognition site.

Original languageEnglish
Pages (from-to)S170-S175
JournalClinical Infectious Diseases
Volume17
DOIs
StatePublished - Aug 1993
Externally publishedYes

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