Interaction of morphine and naloxone in acute spinal cats

J. Goldfarb, E. I. Kaplan, H. R. Jenkins

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Naloxone (0.2 mg/kg i.v.) increased both monosynaptic and polysynaptic reflex amplitudes in acute spinal cats. The increase in monosynaptic reflex amplitude was greater than that for polysynaptic reflexes. Morphine administered intravenously. 36 min following naloxone, depressed monosynaptic reflexes at 3 and 12 mg/kg, and polysynaptic reflexes at 12 mg/kg. A subsequent 0.2 mg/kg dose of naloxone was administered 54 min after beginning the morphine injection. The action of naloxone on polysynaptic reflexes was enhanced by intervening morphine; that on monosynaptic reflexes was not. The actions of morphine and naloxone in these studies do not appear to involve cholinergic synapses in the spinal cord.

Original languageEnglish
Pages (from-to)569-575
Number of pages7
Issue number8
StatePublished - Aug 1978
Externally publishedYes


  • cat
  • monosynaptic reflex
  • morphine
  • naloxone
  • polysynaptic reflex
  • spinal cord


Dive into the research topics of 'Interaction of morphine and naloxone in acute spinal cats'. Together they form a unique fingerprint.

Cite this