Abstract
Naloxone (0.2 mg/kg i.v.) increased both monosynaptic and polysynaptic reflex amplitudes in acute spinal cats. The increase in monosynaptic reflex amplitude was greater than that for polysynaptic reflexes. Morphine administered intravenously. 36 min following naloxone, depressed monosynaptic reflexes at 3 and 12 mg/kg, and polysynaptic reflexes at 12 mg/kg. A subsequent 0.2 mg/kg dose of naloxone was administered 54 min after beginning the morphine injection. The action of naloxone on polysynaptic reflexes was enhanced by intervening morphine; that on monosynaptic reflexes was not. The actions of morphine and naloxone in these studies do not appear to involve cholinergic synapses in the spinal cord.
| Original language | English |
|---|---|
| Pages (from-to) | 569-575 |
| Number of pages | 7 |
| Journal | Neuropharmacology |
| Volume | 17 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1978 |
| Externally published | Yes |
Keywords
- cat
- monosynaptic reflex
- morphine
- naloxone
- polysynaptic reflex
- spinal cord